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肺腺癌患者的肺孢子菌肺炎:帕博利珠单抗的早期副作用

Pneumocystis pneumonia in patient with lung adenocarcinoma: early side effects from pembrolizumab.

作者信息

Hiba Zahi, Abdelmoughit Hosni, Zaynab Iraqi Houssaini, Hounaida Jerguigue, Rachida Latib, Youssef Omor

机构信息

Radiology Department, National Institute of Oncology, Ibn Sina Hospital, Mohammed V University, Rabat, Morocco.

出版信息

Radiol Case Rep. 2022 Aug 17;17(10):3979-3981. doi: 10.1016/j.radcr.2022.07.083. eCollection 2022 Oct.

DOI:10.1016/j.radcr.2022.07.083
PMID:36032207
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9411188/
Abstract

Immune check point inhibitor has made far-reaching changes in the management of lung adenocarcinoma improving drastically the prognosis. We present a case of a 50 years old women beneficiary of pembrolizumab who has suffered an acute pneumonitis diagnosed with CT imaging the days following the initiation of the drug. The occurrence of immune-related events such as pneumonitis complicates the use of immunotherapy and requires a well verse radiologist in the matter to diagnosis and helps prevent further aggravation.

摘要

免疫检查点抑制剂在肺腺癌的治疗管理方面带来了深远变革,极大地改善了预后。我们报告一例50岁女性患者,她是帕博利珠单抗的受益者,在开始使用该药物几天后,经CT成像诊断出患有急性肺炎。免疫相关事件如肺炎的发生使免疫治疗的应用变得复杂,这需要在该领域经验丰富的放射科医生进行诊断,并有助于防止病情进一步加重。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a873/9411188/4883bdf092bd/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a873/9411188/0aa58a133a3a/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a873/9411188/c8132f2483f9/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a873/9411188/4883bdf092bd/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a873/9411188/0aa58a133a3a/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a873/9411188/c8132f2483f9/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a873/9411188/4883bdf092bd/gr3.jpg

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Front Pharmacol. 2023 Mar 15;14:1129730. doi: 10.3389/fphar.2023.1129730. eCollection 2023.
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Intern Med. 2023 Nov 15;62(22):3381-3385. doi: 10.2169/internalmedicine.1163-22. Epub 2023 Mar 31.

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J Immunother Precis Oncol. 2020 Feb 10;3(1):27-30. doi: 10.4103/JIPO.JIPO_23_19. eCollection 2020 Feb.
2
Immune Checkpoint Inhibitor Therapy-related Pneumonitis: Patterns and Management.免疫检查点抑制剂治疗相关的肺炎:类型和管理。
Radiographics. 2019 Nov-Dec;39(7):1923-1937. doi: 10.1148/rg.2019190036. Epub 2019 Oct 4.
3
Immunosuppression for Immune Checkpoint-related Toxicity Can Cause Pneumocystis Jirovecii Pneumonia (PJP) in Non-small-cell Lung Cancer (NSCLC): A Report of 2 Cases.
免疫检查点相关毒性的免疫抑制可导致非小细胞肺癌(NSCLC)患者发生耶氏肺孢子菌肺炎(PJP):2例报告
Clin Lung Cancer. 2019 May;20(3):e247-e250. doi: 10.1016/j.cllc.2018.12.006. Epub 2018 Dec 19.
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Risk factors for pneumonitis in patients treated with anti-programmed death-1 therapy: A case-control study.抗程序性死亡-1 治疗患者肺炎的风险因素:一项病例对照研究。
Cancer Med. 2018 Aug;7(8):4115-4120. doi: 10.1002/cam4.1579. Epub 2018 May 23.
5
Immune-checkpoint inhibitors associated with interstitial lung disease in cancer patients.免疫检查点抑制剂与癌症患者的间质性肺病相关。
Eur Respir J. 2017 Aug 10;50(2). doi: 10.1183/13993003.00050-2017. Print 2017 Aug.
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J Clin Oncol. 2017 Mar;35(7):709-717. doi: 10.1200/JCO.2016.68.2005. Epub 2016 Sep 30.
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Incidence of Programmed Cell Death 1 Inhibitor-Related Pneumonitis in Patients With Advanced Cancer: A Systematic Review and Meta-analysis.程序性细胞死亡蛋白 1 抑制剂相关肺炎在晚期癌症患者中的发生率:系统评价和荟萃分析。
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8
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9
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10
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