Department of Respiratory Medicine and Allergology, Sapporo Medical University School of Medicine, Japan.
Department of Pulmonary Medicine, Hakodate Goryoukaku Hospital, Japan.
Intern Med. 2023 Nov 15;62(22):3381-3385. doi: 10.2169/internalmedicine.1163-22. Epub 2023 Mar 31.
Pneumocystis pneumonia (PCP) is an opportunistic infection that presents a ground-glass appearance in the lungs on chest radiography. Interstitial lung disease is a commonly reported adverse effect of immune checkpoint inhibitor (ICI) treatment; however, there are few reports of ICI treatment-associated PCP infection. A 77-year-old man with lung adenocarcinoma was administered pembrolizumab and hospitalized for dyspnea 2 weeks after treatment. Chest computed tomography showed bilateral ground-glass opacities in all lung lobes. PCP was therefore diagnosed, and steroids and sulfamethoxazole-trimethoprim were initiated. Following treatment, the patient's condition improved promptly. This report suggests that ICI treatment can cause PCP infection.
卡氏肺孢子虫肺炎（PCP）是一种机会性感染，在胸部 X 射线摄影中呈现出磨玻璃样外观。间质性肺疾病是免疫检查点抑制剂（ICI）治疗的常见不良反应；然而，很少有报道称 ICI 治疗相关的 PCP 感染。一名 77 岁男性患有肺腺癌，接受了 pembrolizumab 治疗，治疗后 2 周因呼吸困难住院。胸部计算机断层扫描显示所有肺叶均有双侧磨玻璃样混浊。因此诊断为 PCP，并开始使用类固醇和磺胺甲恶唑-甲氧苄啶治疗。治疗后，患者的病情迅速改善。本报告提示 ICI 治疗可引起 PCP 感染。
