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肺腺癌患者接受派姆单抗治疗后引发肺囊虫肺炎感染。

Pneumocystis Pneumonia Infection Following the Initiation of Pembrolizumab Therapy for Lung Adenocarcinoma.

机构信息

Department of Respiratory Medicine and Allergology, Sapporo Medical University School of Medicine, Japan.

Department of Pulmonary Medicine, Hakodate Goryoukaku Hospital, Japan.

出版信息

Intern Med. 2023 Nov 15;62(22):3381-3385. doi: 10.2169/internalmedicine.1163-22. Epub 2023 Mar 31.

DOI:10.2169/internalmedicine.1163-22
PMID:37005268
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10713372/
Abstract

Pneumocystis pneumonia (PCP) is an opportunistic infection that presents a ground-glass appearance in the lungs on chest radiography. Interstitial lung disease is a commonly reported adverse effect of immune checkpoint inhibitor (ICI) treatment; however, there are few reports of ICI treatment-associated PCP infection. A 77-year-old man with lung adenocarcinoma was administered pembrolizumab and hospitalized for dyspnea 2 weeks after treatment. Chest computed tomography showed bilateral ground-glass opacities in all lung lobes. PCP was therefore diagnosed, and steroids and sulfamethoxazole-trimethoprim were initiated. Following treatment, the patient's condition improved promptly. This report suggests that ICI treatment can cause PCP infection.

摘要

卡氏肺孢子虫肺炎（PCP）是一种机会性感染，在胸部 X 射线摄影中呈现出磨玻璃样外观。间质性肺疾病是免疫检查点抑制剂（ICI）治疗的常见不良反应；然而，很少有报道称 ICI 治疗相关的 PCP 感染。一名 77 岁男性患有肺腺癌，接受了 pembrolizumab 治疗，治疗后 2 周因呼吸困难住院。胸部计算机断层扫描显示所有肺叶均有双侧磨玻璃样混浊。因此诊断为 PCP，并开始使用类固醇和磺胺甲恶唑-甲氧苄啶治疗。治疗后，患者的病情迅速改善。本报告提示 ICI 治疗可引起 PCP 感染。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc9b/10713372/5a759b7111a2/1349-7235-62-3381-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc9b/10713372/b7831952eb58/1349-7235-62-3381-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc9b/10713372/13aff39bf65e/1349-7235-62-3381-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc9b/10713372/5a759b7111a2/1349-7235-62-3381-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc9b/10713372/b7831952eb58/1349-7235-62-3381-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc9b/10713372/13aff39bf65e/1349-7235-62-3381-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc9b/10713372/5a759b7111a2/1349-7235-62-3381-g003.jpg

相似文献

[1]
Pneumocystis Pneumonia Infection Following the Initiation of Pembrolizumab Therapy for Lung Adenocarcinoma.

Intern Med. 2023-11-15

[2]
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[3]
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[7]
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[9]
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[10]
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引用本文的文献

[1]
Pneumocystis jirovecii pneumonia in patients with lung cancer receiving immune checkpoint inhibitors: a retrospective nationwide population-based cohort study from South Korea.

Discov Oncol. 2025-5-30

本文引用的文献

[1]
Pneumocystis pneumonia in patient with lung adenocarcinoma: early side effects from pembrolizumab.

Radiol Case Rep. 2022-8-17

[2]
Pneumocystis Infection in Two Patients Treated with Both Immune Checkpoint Inhibitor and Corticoids.

J Immunother Precis Oncol. 2020-2-10

[3]
Pathophysiological mechanism of non-HIV Pneumocystis jirovecii pneumonia.

Respir Investig. 2022-7

[4]
Transmission and Colonization of .

J Fungi (Basel). 2021-11-18

[5]
An Usual Presentation of Pneumocystis jirovecii Pneumonia in a Woman Treated With Immune Checkpoint Inhibitor.

J Pediatr Hematol Oncol. 2021-3-1

[6]
PD-1 Deficiency Promotes Macrophage Activation and T-Helper Cell Type 1/T-Helper Cell Type 17 Response in Pneumonia.

Am J Respir Cell Mol Biol. 2020-6

[7]
Aging and Lung Disease.

Annu Rev Physiol. 2019-11-15

[8]
Reactivation of tuberculosis in cancer patients following administration of immune checkpoint inhibitors: current evidence and clinical practice recommendations.

J Immunother Cancer. 2019-9-4

[9]
Paradoxical response in a patient with non-small cell lung cancer who received nivolumab followed by anti-Mycobacterium tuberculosis agents.

J Infect Chemother. 2019-1

[10]
Pneumonitis in Patients Treated With Anti-Programmed Death-1/Programmed Death Ligand 1 Therapy.

J Clin Oncol. 2017-3

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