Sasabayashi Daiki, Takayanagi Yoichiro, Takahashi Tsutomu, Furuichi Atsushi, Kobayashi Haruko, Noguchi Kyo, Suzuki Michio
Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, Toyama, Japan.
Research Center for Idling Brain Science, University of Toyama, Toyama, Japan.
Front Psychiatry. 2022 Aug 10;13:937605. doi: 10.3389/fpsyt.2022.937605. eCollection 2022.
Most schizophrenia patients experience psychotic relapses, which may compromise long-term outcome. However, it is difficult to objectively assess the actual risk of relapse for each patient as the biological changes underlying relapse remain unknown. The present study used magnetic resonance imaging (MRI) to investigate the relationship between brain gyrification pattern and subsequent relapse in patients with first-episode schizophrenia. The subjects consisted of 19 patients with and 33 patients without relapse during a 3-year clinical follow-up after baseline MRI scanning. Using FreeSurfer software, we compared the local gyrification index (LGI) between the relapsed and non-relapsed groups. In the relapsed group, we also explored the relationship among LGI and the number of relapses and time to first relapse after MRI scanning. Relapsed patients exhibited a significantly higher LGI in the bilateral parietal and left occipital areas than non-relapsed patients. In addition, the time to first relapse was negatively correlated with LGI in the right inferior temporal cortex. These findings suggest that increased LGI in the temporo-parieto-occipital regions in first-episode schizophrenia patients may be a potential prognostic biomarker that reflects relapse susceptibility in the early course of the illness.
大多数精神分裂症患者会经历精神病性复发，这可能会影响长期预后。然而，由于复发背后的生物学变化尚不清楚，因此很难客观评估每个患者实际的复发风险。本研究使用磁共振成像（MRI）来研究首发精神分裂症患者的脑回状模式与随后复发之间的关系。研究对象包括在基线MRI扫描后进行3年临床随访期间复发的19例患者和未复发的33例患者。使用FreeSurfer软件，我们比较了复发组和未复发组之间的局部脑回指数（LGI）。在复发组中，我们还探讨了LGI与复发次数以及MRI扫描后首次复发时间之间的关系。复发患者双侧顶叶和左侧枕叶区域的LGI显著高于未复发患者。此外，首次复发时间与右下颞叶皮质的LGI呈负相关。这些发现表明，首发精神分裂症患者颞顶枕区域LGI升高可能是一种潜在的预后生物标志物，反映了疾病早期的复发易感性。
