Wang Lian, Wang Xuefei, Guo Zhiwei, Xia Yajuan, Geng Minjie, Liu Dan, Zhang Zhiqiang, Yang Ying
College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, China.
College of Veterinary Medicine, Henan University of Animal Husbandry and Economy, Zhengzhou, China.
Front Vet Sci. 2022 Aug 11;9:857064. doi: 10.3389/fvets.2022.857064. eCollection 2022.
In this study, we synthesized nano-microemulsions of calcium carbonate (CaCO)-encapsulated curcumin (Cur)-Ferulic acid (FA) ester derivatives of diverse mass ratios by using the solution casting approach. The structures, antioxidant and antimicrobial activities, physical properties, and potential of hydrogen (pH) sensitivity of these products were examined. Compared with microparticles of CaCO, those of CaCO@Cur-FA exhibited excellent antimicrobial and antioxidant properties. Response to pH was indicated through the release of Cur-FA from CaCO@Cur-FA in solutions having different pH values. The results demonstrated that Cur-FA was released more quickly from CaCO@Cur-FA at pH 5.5 than at pH 7.4. CaCO@Cur-FA demonstrated good antioxidant capacities through its ability to scavenge 2,2'-amino-di(2-ethyl-benzothiazoline sulphonic acid-6)ammonium salt (ABTS) and 1,1-diphenyl-2-picrylhydrazyl (DPPH). These activities were three-fold more than those observed in CaCO microparticle control groups; additionally, the antimicrobial activity against and increased by 40.5 and 54.6%, respectively. Overall, the microparticles of CaCO@Cur-FA outperformed Cur-FA in terms of antimicrobial properties by inhibiting the growth of certain zoonotic pathogens.
在本研究中，我们采用溶液浇铸法合成了不同质量比的碳酸钙（CaCO）包裹姜黄素（Cur）-阿魏酸（FA）酯衍生物的纳米微乳液。对这些产品的结构、抗氧化和抗菌活性、物理性质以及氢（pH）敏感性潜力进行了研究。与CaCO微粒相比，CaCO@Cur-FA微粒表现出优异的抗菌和抗氧化性能。通过在不同pH值的溶液中从CaCO@Cur-FA释放Cur-FA来表明对pH的响应。结果表明，在pH 5.5时，Cur-FA从CaCO@Cur-FA中的释放速度比在pH 7.4时更快。CaCO@Cur-FA通过清除2,2'-氨基-二（2-乙基-苯并噻唑啉磺酸-6）铵盐（ABTS）和1,1-二苯基-2-苦基肼（DPPH）的能力表现出良好的抗氧化能力。这些活性比在CaCO微粒对照组中观察到的活性高两倍；此外，对[具体细菌1]和[具体细菌2]的抗菌活性分别提高了40.5%和54.6%。总体而言，CaCO@Cur-FA微粒通过抑制某些人畜共患病原体的生长，在抗菌性能方面优于Cur-FA。
