Tsiorou Kyriaki, Sarantaki Antigoni
Department of Midwifery, University of West Attica, Egaleo 12243, Athens, Greece.
Maedica (Bucur). 2022 Jun;17(2):449-457. doi: 10.26574/maedica.2022.17.2.449.
Recent studies have shown that pregnant women were more likely to experience COVID-19 complications than non-pregnant women, especially during the third trimester. Thus, the objective of the present systematic review is to investigate the literature so as to estimate the safety of COVID-19 vaccination during gestation, regardless of the trimester of pregnancy. This systematic review was performed based on PRISMA statement and our search included four databases: Medline, PubMed, EMBASE and Google Scholar. Original studies were included. The following search terms were used: coronavirus disease, coronavirus, COVID-19, SARS-CoV-2, vaccine, vaccination, immunity, immunization, pregnancy, gestation, pregnant women, adverse outcomes, impact, safety, risk assessment and all possible combinations between them. The search strategy identified 153 unique items. After the initial screening process, 12 studies underwent full text review and five studies, which met all inclusion criteria, were ultimately included in our systematic review. All four studies claim that COVID-19 vaccination does not have a negative influence on pregnancy and can be beneficial for both the women and their newborns. More clinical trials assessing pregnancy outcome and the value of COVID-19 vaccines in pregnant women are urgently needed. It is vital to determine the most appropriate timing of vaccination across the three trimesters of pregnancy in order to optimize the balance between vaccine efficacy and maternal and foetal safety. Future studies should evaluate the maternal.neonatal transfer of SARS-CoV-2 antibodies as well as long-term infant outcome after administration of the COVID-19 vaccine prenatally.
最近的研究表明，与未怀孕的女性相比，孕妇更有可能出现新冠病毒疾病并发症，尤其是在孕晚期。因此，本系统评价的目的是对文献进行调查，以评估孕期接种新冠病毒疫苗的安全性，无论处于孕期的哪个阶段。本系统评价依据PRISMA声明进行，我们的检索纳入了四个数据库：医学索引数据库、医学期刊数据库、荷兰医学文摘数据库和谷歌学术。纳入原始研究。使用了以下检索词：冠状病毒病、冠状病毒、新冠病毒疾病、严重急性呼吸综合征冠状病毒2、疫苗、接种疫苗、免疫、免疫接种、妊娠、孕期、孕妇、不良结局、影响、安全性、风险评估以及它们之间的所有可能组合。检索策略共识别出153个独特条目。经过初步筛选过程，12项研究进入全文评审，最终有5项符合所有纳入标准的研究被纳入我们的系统评价。所有四项研究均声称，接种新冠病毒疫苗对妊娠没有负面影响，对孕妇及其新生儿均有益。迫切需要更多评估孕妇妊娠结局和新冠病毒疫苗价值的临床试验。确定孕期三个阶段最合适的接种时间，以优化疫苗效力与母婴安全之间的平衡至关重要。未来的研究应评估严重急性呼吸综合征冠状病毒2抗体的母婴转移情况以及产前接种新冠病毒疫苗后的婴儿长期结局。
