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伴有髋臼骨缺损的全髋关节置换翻修术:生物移植物真的比合成骨移植替代物更好吗?

Revision of Total Hip Arthroplasty with Acetabular Bone Defects: Are Biological Grafts Really Better than Synthetic Bone Graft Substitutes?

作者信息

Comba Luca Costanzo, Bellato Enrico, Colombero Danilo, Mattei Lorenzo, Marmotti Antongiulio, Castoldi Filippo

机构信息

University of Turin, Italy.

San Luigi Gonzaga Hospital, University of Turin Medical School, Orbassano, Turin, Italy.

出版信息

Arch Bone Jt Surg. 2022 Jul;10(7):568-575. doi: 10.22038/ABJS.2021.53380.2666.

Abstract

BACKGROUND

Acetabular aseptic loosening due to bone defect in total hip arthroplasty revisions is a great challenge and several solutions have been proposed, but a broadly accepted consensus in the literature has not been reached yet. The aim of this study is to compare the clinical and radiographic results of acetabular bone defects treatment with biological-only graft or with a mixture of bone graft substitute and biological graft.

METHODS

33 patients had revision hip arthroplasty using impaction grafting with biological-only graft (21 patients, Group A) or a 1/3 mixture of allograft and tricalcium phosphate bone graft substitute (12 patients, Group B). Patients were reassessed at a minimum of one year after surgery with new x-rays and the Harris Hip Score (HHS).

RESULTS

Survivorship of bone graft was 86% in Group A and 100% in Group B at a mean follow-up of 35 months. No statistical difference between the two groups was found in terms of implants survivorship (), clinical () or radiographic (7) outcomes.

CONCLUSION

In our experience the use of tricalcium phosphate bone graft substitutes in combination with allo and autograft provides good outcomes, low risk of failure and great clinical and radiographic results. Further investigations on larger samples are needed to impact clinical practice.

摘要

背景

全髋关节置换翻修术中因骨缺损导致的髋臼无菌性松动是一项巨大挑战,人们已经提出了多种解决方案,但尚未在文献中达成广泛认可的共识。本研究的目的是比较单纯使用生物骨移植或使用骨移植替代物与生物骨移植混合物治疗髋臼骨缺损的临床和影像学结果。

方法

33例患者接受了髋关节翻修术,其中21例患者采用单纯生物骨打压植骨(A组),12例患者采用同种异体骨与磷酸三钙骨移植替代物1/3的混合物植骨(B组)。术后至少一年,通过新的X线片和Harris髋关节评分(HHS)对患者进行重新评估。

结果

平均随访35个月时,A组骨移植的生存率为86%,B组为100%。两组在植入物生存率、临床结果或影像学结果方面均未发现统计学差异。

结论

根据我们的经验,磷酸三钙骨移植替代物与同种异体骨和自体骨联合使用可提供良好的结果、低失败风险以及出色的临床和影像学结果。需要对更大样本进行进一步研究以影响临床实践。

相似文献

本文引用的文献

1
Osteolysis as it Pertains to Total Hip Arthroplasty.与全髋关节置换术相关的骨质溶解
Orthop Clin North Am. 2018 Oct;49(4):419-435. doi: 10.1016/j.ocl.2018.06.001.
10
Bone substitutes in orthopaedic surgery: from basic science to clinical practice.骨科手术中的骨替代物:从基础科学到临床实践
J Mater Sci Mater Med. 2014 Oct;25(10):2445-61. doi: 10.1007/s10856-014-5240-2. Epub 2014 May 28.

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