ON donor tethered copper (II) and vanadium (V) complexes as efficacious anti-TB and anti-fungal agents with spectroscopic approached HSA interactions.

Antimicrobial drug resistance poses a significant threat worldwide, hence triggering an urgent situation for developing feasible drugs. 3D-transition metal coordination complexes being multifaceted, offer tremendous potency as drug candidates. However, there are fewer reports on non-toxic and safe transition metal complexes; therefore, we hereby attempted to develop novel copper and vanadium-based therapeutic agents. We have synthesised six metal complexes , [VO(Quibal-INH)] , [Cu(Quibal-INH)] , [VO(Quibal-INH) (cat)] , [Cu(Quibal-INH) (cat)] , [VO(Quibal-INH) (bha)] and [Cu(Quibal-INH) (bha)] . Quibal-INH is an ON bidentate donor ligand synthesized from Schiff base reaction between 4-(2-(7-chloroquinolin-3-yl)vinyl)benzaldehyde (Quibal) and Isoniazid (INH). The synthesized compounds were characterized using analytical techniques involving ATR-IR, UV-Vis, EPR, H NMR, C NMR, and V NMR. Ligand and compound exhibited moderate growth inhibitory activity towards and fungal species. Compound has been identified as active against the above fungal species with no toxicity and hemolysis activity on the healthy cells. Compound exhibited significant activity against the strain. Further, compounds , and exhibited excellent free radical scavenging activity. All the developed compounds were found to exhibit stability over a wide range of pH conditions. The complexes were additionally studied for their interaction with human serum albumin (HSA) with the UV-vis spectroscopic technique.