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医学中的钒化合物。

Vanadium compounds in medicine.

作者信息

Pessoa Joao Costa, Etcheverry Susana, Gambino Dinorah

机构信息

Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Av Rovisco Pais, 1049-001 Lisboa, Portugal.

Cátedra de Bioquímica Patológica and CEQUINOR, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, 47 y 115 1900 La Plata, Argentina.

出版信息

Coord Chem Rev. 2015 Oct 15;301:24-48. doi: 10.1016/j.ccr.2014.12.002. Epub 2014 Dec 9.

DOI:10.1016/j.ccr.2014.12.002
PMID:32226091
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7094629/
Abstract

Vanadium is a transition metal that, being ubiquitously distributed in soil, crude oil, water and air, also found roles in biological systems and is an essential element in most living beings. There are also several groups of organisms which accumulate vanadium, employing it in their biological processes. Vanadium being a biological relevant element, it is not surprising that many vanadium based therapeutic drugs have been proposed for the treatment of several types of diseases. Namely, vanadium compounds, in particular organic derivatives, have been proposed for the treatment of diabetes, of cancer and of diseases caused by parasites. In this work we review the medicinal applications proposed for vanadium compounds with particular emphasis on the more recent publications. In cells, partly due to the similarity of vanadate and phosphate, vanadium compounds activate numerous signaling pathways and transcription factors; this by itself potentiates application of vanadium-based therapeutics. Nevertheless, this non-specific bio-activity may also introduce several deleterious side effects as in addition, due to Fenton's type reactions or of the reaction with atmospheric O, VCs may also generate reactive oxygen species, thereby introducing oxidative stress with consequences presently not well evaluated, particularly for long-term administration of vanadium to humans. Notwithstanding, the potential of vanadium compounds to treat type 2 diabetes is still an open question and therapies using vanadium compounds for antitumor and anti-parasitic related diseases remain promising.

摘要

钒是一种过渡金属，广泛分布于土壤、原油、水和空气中，在生物系统中也发挥着作用，是大多数生物体内的必需元素。也有几类生物会积累钒，并在其生物过程中利用它。由于钒是一种与生物相关的元素，因此提出了许多基于钒的治疗药物来治疗几种类型的疾病也就不足为奇了。具体而言，钒化合物，特别是有机衍生物，已被提议用于治疗糖尿病、癌症和由寄生虫引起的疾病。在这项工作中，我们回顾了钒化合物的药用应用，特别强调了最近的出版物。在细胞中，部分由于钒酸盐和磷酸盐的相似性，钒化合物激活了许多信号通路和转录因子；这本身就增强了基于钒的治疗方法的应用。然而，这种非特异性生物活性也可能带来一些有害的副作用，此外，由于芬顿型反应或与大气中的氧气反应，钒化合物还可能产生活性氧，从而引入氧化应激，其后果目前尚未得到很好的评估，特别是对于长期给人类服用钒的情况。尽管如此，钒化合物治疗2型糖尿病的潜力仍然是一个悬而未决的问题，使用钒化合物治疗抗肿瘤和抗寄生虫相关疾病的疗法仍然很有前景。

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