Cheng Kunming, Guo Qiang, Shen Zefeng, Yang Weiguang, Zhou Yan, Sun Zaijie, Yao Xiuhua, Wu Haiyang
Department of Intensive Care Unit, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Department of Orthopaedic Surgery, Baodi Clinical College of Tianjin Medical University, Tianjin, China.
Front Oncol. 2022 Aug 11;12:948389. doi: 10.3389/fonc.2022.948389. eCollection 2022.
In recent years, ferroptosis has become a research hotspot in programmed cell death. Since the concept of ferroptosis was proposed, a growing number of articles have been published on this topic. Nevertheless, to our knowledge, these ferroptosis-related publications that have received a great deal of attention have not been quantitatively evaluated. In this study, we analyzed the top 100 most influential articles over the past decade through a bibliometric method to characterize the research status and trends in this field. Web of Science Core Collection was searched to identify relevant studies. After being manually screened, the top 100 most cited studies with original data were identified and analyzed. Bibliometric software including VOSviewer and R-Bibliometrix were used to perform visualization analysis. The citation frequency for the top 100 selected articles ranged from 135 to 3603 (326.6 citations on average). These articles originated from 25 countries/regions, with more than half originating from the United States and China. The most frequently nominated author was Stockwell BR from the Columbia University, and of the top 100 articles, 19 listed his name. Three core journals were , and . In addition to term of ferroptosis, these terms or phrases including cell death, cancer cell, GPX4, pathway, inhibitor, mechanism, iron, lipid peroxidation, resistance, erastin, sorafenib, P53, reactive oxygen species, necroptosis, apoptosis, glutathione peroxidase, ACSL4, autophagy, and SLC7A11 appeared more frequently in the top 100 articles. Overall, although much progress has been made, the research on ferroptosis is still at an early stage. The current attention in this field mainly focuses on potential regulatory mechanism and pathways including key ferroptosis-related genes/molecules, oxidant and antioxidant system, ferroptosis-inducing agents or nanomedicine for cancer therapy, as well as the role of ferroptosis in non-neoplastic disorders. Meanwhile, combination therapeutic strategies targeting ferroptosis in radiotherapy or immunotherapy also deserve further attention.
近年来，铁死亡已成为程序性细胞死亡领域的研究热点。自铁死亡概念提出以来，关于该主题的文章发表数量日益增多。然而，据我们所知，这些备受关注的铁死亡相关出版物尚未得到定量评估。在本研究中，我们通过文献计量学方法分析了过去十年中最具影响力的100篇文章，以表征该领域的研究现状和趋势。我们检索了Web of Science核心合集以识别相关研究。经过人工筛选，确定并分析了100篇被引用次数最多且有原始数据的研究。使用包括VOSviewer和R-Bibliometrix在内的文献计量软件进行可视化分析。入选的100篇文章的被引频次范围为135至3603次（平均326.6次引用）。这些文章来自25个国家/地区，其中一半以上来自美国和中国。被提名次数最多的作者是哥伦比亚大学的斯托克韦尔·B·R，在100篇文章中有19篇列出了他的名字。三本核心期刊分别是《》《》和《》。除了铁死亡这一术语外，包括细胞死亡、癌细胞、谷胱甘肽过氧化物酶4（GPX4）、信号通路、抑制剂、机制、铁、脂质过氧化、抗性、埃拉斯汀、索拉非尼、P53、活性氧、坏死性凋亡、凋亡、谷胱甘肽过氧化物酶、长链脂酰辅酶A合成酶4（ACSL4）、自噬和溶质载体家族7成员11（SLC7A11）等术语或短语在这100篇文章中出现的频率更高。总体而言，尽管已取得很大进展，但铁死亡的研究仍处于早期阶段。该领域目前的关注主要集中在潜在的调控机制和信号通路上，包括关键的铁死亡相关基因/分子、氧化和抗氧化系统、用于癌症治疗的铁死亡诱导剂或纳米药物，以及铁死亡在非肿瘤性疾病中的作用。同时，在放射治疗或免疫治疗中针对铁死亡的联合治疗策略也值得进一步关注。
