Saad Mohammed Abd Elmeged Lobna, Salem Helal Alzahrani Magbolah
Department of Home Economics-Nutrition, AL-Baha University, AlMakhwa, Saudi Arabia.
Biology Department, Faculty of Science, AL-Baha University, Saudi Arabia.
Saudi J Biol Sci. 2022 Oct;29(10):103374. doi: 10.1016/j.sjbs.2022.103374. Epub 2022 Jul 28.
The liver is more prone to infections that cause fibrosis, such as steatosis, non-alcoholic steatohepatitis, hepatotoxicity, cirrhosis, and hepatocellular carcinoma. Also, Viral hepatitis is a common condition worldwide it worsens into chronic inflammation of the liver. One of the healthiest fruits is the pomegranate for the body and health, as it contains a high nutritional value of minerals, vitamins, antioxidants, so we worked on this investigation to magnify the therapeutic applications of pomegranate fruits (POF) and peel (POP) in carbon tetrachloride-injected rats (Ccl4). The experiment was carried out in a caged animal. All rats were fed a basal diet for one week before the study, and they were divided into seven groups, each with six rats. As a control negative group (C-ve), the first group sample was fed only the basal diet for 28 days. The remaining rats (n = 36) were injected with carbon tetrachloride (Ccl4). Five groups were fed varying concentrations of (5 %, 10 %, 15 % POF, 5 %, and 10 % pomegranate peel (POP)), whereas one group was diagnosed with the illness and disease, and didn't even feed the experimental diet. The results revealed significant increases in T.BIL, D.BIL, and BIL in the serum of rats injected by CC14 to induce hepatopathy compared to the healthy group (normal rats). Also, the best treatment considering the serum D.BIL was recorded for the 5 % POF.
肝脏更容易受到导致纤维化的感染，如脂肪变性、非酒精性脂肪性肝炎、肝毒性、肝硬化和肝细胞癌。此外，病毒性肝炎是一种全球常见的疾病，它会恶化为肝脏的慢性炎症。石榴是对身体和健康最有益的水果之一，因为它含有高营养价值的矿物质、维生素、抗氧化剂，所以我们进行了这项研究，以扩大石榴果实（POF）和果皮（POP）在注射四氯化碳的大鼠（Ccl4）中的治疗应用。实验在笼养动物中进行。在研究前，所有大鼠均喂食基础饮食一周，然后将它们分为七组，每组六只大鼠。作为阴性对照组（C-ve），第一组样本仅喂食基础饮食28天。其余大鼠（n = 36）注射四氯化碳（Ccl4）。五组分别喂食不同浓度的（5%、10%、15%的POF、5%和10%的石榴皮（POP）），而有一组被诊断患有疾病，甚至不喂食实验饮食。结果显示，与健康组（正常大鼠）相比，注射CC14诱导肝病的大鼠血清中的总胆红素（T.BIL）、直接胆红素（D.BIL）和胆红素（BIL）显著升高。此外，就血清D.BIL而言，5%的POF治疗效果最佳。
