Yadav Arun Kumar, Kotwal Atul, Ghosh Subhadeep
Department of Community Medicine, Armed Forces Medical College, Pune, Maharashtra, India.
Executive Director, NHSRC, New Delhi, India.
Indian J Community Med. 2022 Apr-Jun;47(2):202-206. doi: 10.4103/ijcm.ijcm_684_21. Epub 2022 Jul 11.
Despite the low level of clinical evidence in hydroxychloroquine (HCQ) favor, it was prescribed for pre- and post-exposure prophylaxis in India and worldwide. In absence of a large randomized control trial, the evidence needs to be generated through observation study, hence the study was conducted to find the evidence for prophylaxis of HCQ.
A multi-centric cross-sectional study involving government hospitals was chosen for serosurvey conducted from August 21, 2020, to November 20, 2020. Questionnaire was adopted from WHO. Data about chloroquine (CQ) use among health-care workers (HCWs) were added and the duration of CQ intake was also noted.
A total of 2,224 HCWs were recruited. The mean duration of time of taking HCQ was 7.1 weeks (standard deviation ± 6.1 weeks, median = 4 weeks with IQR, 3-10 weeks). Training on personal protective equipment (PPE), knowledge of handwashing, direct care to the patient, availability of alcohol hand rub, close contact with the patient, duration of contact, and usage of PPE were associated with HCQ intake. The antibody formation in group taking HCQ was 16.9% compared to 19.8% not taking it ( = 0.08). The Chi-square for linear trend for weeks of HCQ intake and antibody formation. However, the same was not statistically significant (Chi-square = 3.61, = 0.06).
Our study did not find a statistically significant association in the large multicentric study. The absolute difference of 2.9% in the two groups may not be sufficient to warrant its widespread use for prophylaxis.
尽管羟氯喹（HCQ）的临床证据支持水平较低，但它在印度和全球范围内都被用于暴露前和暴露后预防。由于缺乏大型随机对照试验，需要通过观察性研究来生成证据，因此开展了本研究以寻找HCQ预防的证据。
选择一项涉及政府医院的多中心横断面研究进行血清学调查，研究时间为2020年8月21日至2020年11月20日。问卷采用世界卫生组织的。增加了医护人员（HCWs）使用氯喹（CQ）的数据，并记录了CQ的摄入持续时间。
共招募了2224名医护人员。服用HCQ的平均时间为7.1周（标准差±6.1周，中位数 = 4周，四分位间距为3 - 10周）。关于个人防护装备（PPE）的培训、洗手知识、对患者的直接护理、酒精擦手液的可用性、与患者的密切接触、接触持续时间以及PPE的使用与HCQ摄入有关。服用HCQ组的抗体形成率为16.9%，未服用组为19.8%（P = 0.08）。HCQ摄入周数与抗体形成的线性趋势卡方检验。然而，该结果无统计学意义（卡方 = 3.61，P = 0.06）。
我们的研究在大型多中心研究中未发现统计学上的显著关联。两组2.9%的绝对差异可能不足以保证其广泛用于预防。
