Division of Infectious Disease, Department of Internal Medicine, Pusan National University School of Medicine and Medical Research Institute, Pusan National University Hospital, 179 Gudeok-ro, Seo-gu, Busan, 49241, Republic of Korea.
Busan Center for Infectious Disease Control and Prevention, Pusan National University Hospital and Epidemic Investigation Team of Busan Metropolitan City, 1001 Jungang-daero, Yeonje-gu, Busan, 47545, Republic of Korea.
Int J Antimicrob Agents. 2020 Jun;55(6):105988. doi: 10.1016/j.ijantimicag.2020.105988. Epub 2020 Apr 17.
In the context of the ongoing global outbreak of coronavirus disease 2019 (COVID-19), management of exposure events is a concern. Long-term care hospitals (LTCHs) are particularly vulnerable to cluster outbreaks because facilities for patient isolation and healthcare personnel to care for these patients in isolation are difficult to arrange in a large outbreak situation. Although several drugs have been proposed as treatment options, there are no data on the effectiveness and safety of post-exposure prophylaxis (PEP) for COVID-19. After a large COVID-19 exposure event in an LTCH in Korea, PEP using hydroxychloroquine (HCQ) was administered to 211 individuals, including 189 patients and 22 careworkers, whose baseline polymerase chain reaction (PCR) tests for COVID-19 were negative. PEP was completed in 184 (97.4%) patients and 21 (95.5%) careworkers without serious adverse events. At the end of 14 days of quarantine, all follow-up PCR tests were negative. Based on our experience, further clinical studies are recommended for COVID-19 PEP.
在 2019 年冠状病毒病（COVID-19）全球疫情持续的背景下，接触事件的管理是一个关注点。长期护理医院（LTCH）特别容易发生集群性暴发，因为在大规模暴发情况下，难以安排患者隔离设施和医护人员对这些患者进行隔离护理。尽管已经提出了几种药物作为治疗选择，但 COVID-19 暴露后预防（PEP）的有效性和安全性数据尚不清楚。在韩国一家 LTCH 发生 COVID-19 大规模接触事件后，对包括 189 名患者和 22 名护理人员在内的 211 人使用羟氯喹（HCQ）进行了 PEP，这些人的 COVID-19 基线聚合酶链反应（PCR）检测均为阴性。184 名（97.4%）患者和 21 名（95.5%）护理人员完成了 PEP，未发生严重不良事件。在隔离结束的 14 天内，所有后续的 PCR 检测均为阴性。基于我们的经验，建议对 COVID-19 PEP 进行进一步的临床研究。
