Fatima Tarannum, Faridi Mohammad Moonis Akbar, Srivastava Geetika
ERA's Lucknow Medical College, Lucknow, Uttar Pradesh, India.
Front Pediatr. 2022 Aug 11;10:880431. doi: 10.3389/fped.2022.880431. eCollection 2022.
The effect of maternal iron supplementation during lactation on the iron status of exclusively breastfed low-birth-weight (LBW) infants is not known.
(1) To find out the number of LBW exclusively breastfed infants having hemoglobin < 10.5 g/dL at 6 months when mothers received iron. (2) To find out the proportion of anemic infants when mothers received iron for 3 and 6 months.
The Clinical Trials Registry, India (CTRI) registered trial (CTRI/2018/08/015516) double-blind randomized control trial participants: A total of 80 anemic mothers and exclusively breastfed LBW infants.
A total of 80 anemic mothers and exclusively breastfed infants, birth weight 1,500-2,499 g, randomized into two groups of 40 each. Mothers received daily iron for 3 months and placebo for the next 3 months in group A and iron for 6 months in group B. Iron profile of mothers and infants measured at recruitment and 6 months.
In total, 26.6% infants developed anemia till 6 months of age, and number of anemic infants were similar whether mothers received iron for 3 ( = 9) or 6 months ( = 11). Hemoglobin (12.89 + 0.46 vs. 12.44 + 0.48 g/dL; < 0.001) and serum ferritin (27.45 + 7.60 vs. 18.94 + 5.36 ng/mL; < 0.001) were significantly higher in infants at 6 months of age whose mothers received iron for 6 months in comparison to 3 months. Conclusion: totally, 26.6% exclusively breastfed infants developed anemia till 6 months of age when mothers took iron; number of anemic infants were not different if mothers received iron for 3 or 6 months. A significant increase was noted in serum ferritin with slightly higher hemoglobin of infants when mothers received iron for longer duration.
[http://ctri.nic.in/Clinicaltrials/pubview.php], identifier [CTRI/2018/08/015516].
哺乳期母亲补充铁剂对纯母乳喂养的低出生体重（LBW）婴儿铁状态的影响尚不清楚。
（1）了解母亲接受铁剂时，6个月大的纯母乳喂养的低出生体重婴儿血红蛋白<10.5 g/dL的数量。（2）了解母亲接受3个月和6个月铁剂时贫血婴儿的比例。
印度临床试验注册中心（CTRI）注册试验（CTRI/2018/08/015516）双盲随机对照试验参与者：共有80名贫血母亲及纯母乳喂养的低出生体重婴儿。
共有80名贫血母亲及纯母乳喂养婴儿，出生体重1500 - 2499 g，随机分为两组，每组40名。A组母亲每日服用铁剂3个月，接下来3个月服用安慰剂；B组母亲服用铁剂6个月。在招募时及6个月时测量母亲和婴儿的铁指标。
到6个月大时，共有26.6%的婴儿发生贫血，母亲接受3个月（=9）或6个月（=11）铁剂时贫血婴儿数量相似。与接受3个月铁剂的母亲相比，接受6个月铁剂的母亲在婴儿6个月大时，其婴儿的血红蛋白（12.89 + 0.46 vs. 12.44 + 0.48 g/dL；<0.001）和血清铁蛋白（27.45 + 7.60 vs. 18.94 + 5.36 ng/mL；<0.001）显著更高。结论：母亲服用铁剂时，到6个月大时共有26.6%的纯母乳喂养婴儿发生贫血；母亲接受3个月或6个月铁剂时贫血婴儿数量无差异。当母亲接受更长时间铁剂时，婴儿血清铁蛋白显著增加，血红蛋白略有升高。
[http://ctri.nic.in/Clinicaltrials/pubview.php]，标识符[CTRI/2018/08/015516]。
