Price Kenneth W, Pennesi Mark E, Lauer Andreas K, Bailey Steven T
Casey Eye Institute, Oregon Health and Science University, Portland, OR, USA.
Am J Ophthalmol Case Rep. 2022 Aug 6;27:101677. doi: 10.1016/j.ajoc.2022.101677. eCollection 2022 Sep.
To report a case of iatrogenic choroidal neovascularization (CNV) developing one month after subretinal gene therapy surgery.
A 16-year-old male with biallelic RPE65 mutation associated retinal dystrophy was treated with subretinal voretigene neparvovec in the left eye. During initiation of a balanced salt solution pre-bleb, a faint and transient subretinal hemorrhage was observed at the retinotomy site. One month post-operatively, multi-modal imaging detected a CNV and a break in Bruch's membrane at the retinotomy site. The asymptomatic CNV was observed without treatment and resolved spontaneously.
CONCLUSIONS & IMPORTANCE: As subretinal gene therapy surgery becomes more common, clinicians should monitor for possible trauma induced CNV associated with retinotomy formation and subretinal injection.
报告1例视网膜下基因治疗手术后1个月发生医源性脉络膜新生血管（CNV）的病例。
一名16岁双等位基因RPE65突变相关视网膜营养不良男性患者接受了左眼视网膜下注射voretigene neparvovec治疗。在开始使用平衡盐溶液进行前房穿刺时，在视网膜切开部位观察到轻微且短暂的视网膜下出血。术后1个月，多模式成像检测到视网膜切开部位有CNV及 Bruch膜破裂。观察到无症状的CNV，未进行治疗，其自行消退。
随着视网膜下基因治疗手术越来越普遍，临床医生应监测与视网膜切开形成和视网膜下注射相关的可能创伤性CNV。
