Apelin-13/APJ系统在脑缺血中的有益作用：发病机制与治疗策略
The beneficial roles of apelin-13/APJ system in cerebral ischemia: Pathogenesis and therapeutic strategies.
作者信息
Li Jiabin, Chen Zhang, Chen Jingyu, Yu Yue
机构信息
Department of Pharmacy, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Department of Tuina, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
出版信息
Front Pharmacol. 2022 Aug 10;13:903151. doi: 10.3389/fphar.2022.903151. eCollection 2022.
The incidence of cerebral ischemia has increased in the past decades, and the high fatality and disability rates seriously affect human health. Apelin is a bioactive peptide and the ligand of the G protein-coupled receptor APJ. Both are ubiquitously expressed in the peripheral and central nervous systems, and regulate various physiological and pathological process in the cardiovascular, nervous and endocrine systems. Apelin-13 is one of the subtypes of apelin, and the apelin-13/APJ signaling pathway protects against cerebral ischemia by promoting angiogenesis, inhibiting excitotoxicity and stabilizing atherosclerotic plaques. In this review, we have discussed the role of apelin-13 in the regulation of cerebral ischemia and the underlying mechanisms, along with the therapeutic potential of the apelin-13/APJ signaling pathway in cerebral ischemia.
在过去几十年中，脑缺血的发病率有所上升，其高死亡率和致残率严重影响人类健康。Apelin是一种生物活性肽，是G蛋白偶联受体APJ的配体。二者均在外周和中枢神经系统中广泛表达，并调节心血管、神经和内分泌系统的各种生理和病理过程。Apelin-13是Apelin的亚型之一，Apelin-13/APJ信号通路通过促进血管生成、抑制兴奋毒性和稳定动脉粥样硬化斑块来预防脑缺血。在本综述中，我们讨论了Apelin-13在脑缺血调节中的作用及其潜在机制，以及Apelin-13/APJ信号通路在脑缺血中的治疗潜力。
Zotero 插件