Department of Neurology, Sichuan Tianfu New District People's Hospital.
Department of Neurology, Sichuan Provincial People's Hospital, Chengdu, China.
Medicine (Baltimore). 2021 Mar 26;100(12):e25184. doi: 10.1097/MD.0000000000025184.
Adipose tissue acts as an active endocrine organ secreting a number of adipokines and may be involved in biological mechanism of stroke. Vaspin, apelin, and visfatin play important roles in the regulation of vascular disorders.Our aim was to evaluate whether the concentrations of vaspin, apelin, and visfatin were associated with stroke risk.A total of 235 patients with stroke (156 patients with ischemic stroke and 79 patients with hemorrhagic stroke) and 235 age- and gender-matched healthy controls were included in this study. A sandwich ELISA was developed to measure the serum vaspin, apelin, and visfatin levels.There was a statistically significant difference in the median levels of serum vaspin, apelin, and visfatin levels between stroke cases and controls (vaspin: 1.50 vs 1.07 ng/ml; apelin: 1.56 vs 1.32 pg/ml; visfatin: 23.40 vs 19.65 ng/ml; all P values <.001). Multiple logistic regression analysis showed that, serum vaspin and visfatin levels were significantly inversely associated with increased risk of stroke, and the odds ratios (ORs) in the highest tertile were 2.25 [95% confidence interval (CI) 1.38-3.67; P for trend <.001] for vaspin and 2.56 (95% CI 1.46-4.47; P for trend <.001) for visfatin, respectively, compared with the lowest tertile. Higher apelin levels were marginally associated with lower stroke risk (P for trend =.060).Our study indicated that higher vaspin, apelin, and visfatin levels might be associated with increased stroke risk. Necessary prospective cohort studies should be conducted to confirm this association in the future.
脂肪组织作为一种活跃的内分泌器官，分泌多种脂肪因子，可能参与中风的生物学机制。内脂素、apelin 和 visfatin 在调节血管紊乱方面发挥着重要作用。我们的目的是评估内脂素、apelin 和 visfatin 的浓度是否与中风风险相关。
这项研究共纳入了 235 例中风患者（156 例缺血性中风，79 例出血性中风）和 235 例年龄和性别匹配的健康对照者。采用夹心 ELISA 法测定血清内脂素、apelin 和 visfatin 水平。
中风组和对照组之间血清内脂素、apelin 和 visfatin 水平的中位数存在统计学差异（内脂素：1.50 与 1.07ng/ml；apelin：1.56 与 1.32pg/ml；visfatin：23.40 与 19.65ng/ml；所有 P 值均<.001）。多因素 logistic 回归分析显示，血清内脂素和 visfatin 水平与中风风险增加显著相关，最高三分位组的比值比（OR）分别为 2.25（95%置信区间 [CI]：1.38-3.67；趋势 P 值<.001）和 2.56（95%CI：1.46-4.47；趋势 P 值<.001），与最低三分位组相比。较高的 apelin 水平与较低的中风风险相关（趋势 P 值=.060）。
我们的研究表明，较高的内脂素、apelin 和 visfatin 水平可能与中风风险增加有关。未来有必要进行前瞻性队列研究来证实这种相关性。
