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补肺汤通过调节Th17/Treg细胞平衡改善大鼠慢性阻塞性肺疾病肺气虚证

Bufei Decoction Improves Lung-Qi Deficiency Syndrome of Chronic Obstructive Pulmonary Disease in Rats by Regulating the Balance of Th17/Treg Cells.

作者信息

Shen Junxi, Zhu Xing, Chen Yunzhi, Li Wen, Liu Huaiquan, Chu Cancan, Zhang Yu, Xu Changjun, Tong Pingzhen, Yu Xinran, Yang Guangyong, Deng Ying

机构信息

School of Basic Medical, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China.

The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang 550003, China.

出版信息

Evid Based Complement Alternat Med. 2022 Aug 17;2022:1459232. doi: 10.1155/2022/1459232. eCollection 2022.

DOI:10.1155/2022/1459232
PMID:36034952
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9402293/
Abstract

Bufei decoction (BFD) has been applied to treat chronic obstructive pulmonary disease (COPD) for centuries as a recognized traditional Chinese herbal formula. However, mechanisms of BFD on COPD are unclear. This study conducts an inquiry into the underlying mechanisms of the therapeutic effect of BFD on COPD. A COPD rat model with qi deficiency in lungs was established through induction using cigarette and sawdust smoking combined with intratracheal instillation of lipopolysaccharide following BFD treatment for 28 days. Changes in Th17/Treg cells of COPD rats with the syndrome of lung qi deficiency after BFD administration were verified using pulmonary function, ELISA, flow cytometry, histopathology, and Western blotting assays. The findings showed that BFD protected COPD rats from decreased lung function and lung injury. BFD administration reduced proinflammatory cytokines IL-6 and IL-17 secretion, promoted inhibitory cytokines IL-10 and TGF- secretion, decreased Th17/Treg cell ratio, markedly downregulated the Th17 cell transcription factor ROR-t expression, and upregulated transcription factor Foxp3 expression in Treg cells. We speculate that lung tonic soup improved pulmonary qi deficiency in rats with COPD by regulating the balance of Th17/Treg cells.

摘要

补肺汤（BFD）作为一种公认的传统中药配方，数世纪以来一直用于治疗慢性阻塞性肺疾病（COPD）。然而，补肺汤治疗COPD的机制尚不清楚。本研究探讨补肺汤治疗COPD的潜在机制。通过香烟和木屑烟熏联合气管内滴注脂多糖诱导建立肺气虚型COPD大鼠模型，给予补肺汤治疗28天。采用肺功能、ELISA、流式细胞术、组织病理学和蛋白质印迹分析等方法，验证补肺汤给药后肺气虚型COPD大鼠Th17/Treg细胞的变化。结果表明，补肺汤可保护COPD大鼠的肺功能下降和肺损伤。补肺汤给药可减少促炎细胞因子IL-6和IL-17的分泌，促进抑制性细胞因子IL-10和TGF-的分泌，降低Th17/Treg细胞比例，显著下调Th17细胞转录因子ROR-γt表达，并上调Treg细胞中转录因子Foxp3表达。我们推测，补肺汤通过调节Th17/Treg细胞平衡改善COPD大鼠的肺气虚。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17c4/9402293/983507eba5da/ECAM2022-1459232.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17c4/9402293/ea713304e25c/ECAM2022-1459232.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17c4/9402293/979df2add707/ECAM2022-1459232.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17c4/9402293/a1d8ef3f0196/ECAM2022-1459232.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17c4/9402293/983507eba5da/ECAM2022-1459232.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17c4/9402293/ea713304e25c/ECAM2022-1459232.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17c4/9402293/979df2add707/ECAM2022-1459232.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17c4/9402293/a1d8ef3f0196/ECAM2022-1459232.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17c4/9402293/983507eba5da/ECAM2022-1459232.004.jpg

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