Department of Gastroenterology, The First Affiliated Hospital, Jinan University, Guangzhou, Guangdong 510630, China.
Department of Gastroenterology, The Third Affiliated Hospital, Jinzhou Medical University, Jinzhou, Liaoning 121001, China.
Oxid Med Cell Longev. 2022 Aug 5;2022:6908934. doi: 10.1155/2022/6908934. eCollection 2022.
To assess the effects of dietary white meat (grass carp and chicken) and red meat (pork and beef) on metabolic parameters, including the intestinal microbiota and its metabolites (SCFAs and bile acids) in NAFLD rats induced by high-fat diet.
NAFLD rats were randomly assigned to five groups: NAFLD group, grass carp group, chicken group, pork group, and beef group (10 rats in each group), and these rats were fed for 8 weeks using the high-fat diet, grass carp-based diet, chicken-based diet, pork-based diet, and beef-based diet, respectively. At the end of the intervention, NAFLD-related metabolic indexes, intestinal flora, and its metabolites were measured.
The grass carp-based diet significantly improved hepatic pathological changes and glycolipid metabolism, and the chicken-based diet only partially improved the metabolic parameters. However, NAFLD progression was observed in the pork group and the beef group. What is more, the white meat-based diet-mediated changes in the enrichment of beneficial bacteria (such as or ), SCFAs, and unconjugated BAs (such as UDCA) and the depletion of pathogenic bacteria (such as and ) and conjugated BAs were observed, while the red meat-based diet-induced changes in the enrichment of pathogenic bacteria ( or ) and conjugated BAs and the depletion of SCFAs and unconjugated BAs were found.
The dietary white meat and red meat modulating gut microbiota and its metabolites may favor and aggravate NAFLD in rats, respectively.
评估白肉（草鱼和鸡肉）和红肉（猪肉和牛肉）饮食对高脂肪饮食诱导的非酒精性脂肪性肝病（NAFLD）大鼠代谢参数的影响，包括肠道微生物群及其代谢产物（短链脂肪酸和胆汁酸）。
将 NAFLD 大鼠随机分为五组：NAFLD 组、草鱼组、鸡肉组、猪肉组和牛肉组（每组 10 只），分别用高脂肪饮食、草鱼饮食、鸡肉饮食、猪肉饮食和牛肉饮食喂养 8 周。干预结束时，测量与 NAFLD 相关的代谢指标、肠道菌群及其代谢产物。
草鱼饮食显著改善了肝脏的病理变化和糖脂代谢，而鸡肉饮食仅部分改善了代谢参数。然而，在猪肉组和牛肉组观察到 NAFLD 进展。更重要的是，白肉饮食介导的有益菌（如 或 ）、短链脂肪酸（SCFAs）和非结合胆汁酸（如 UDCA）的富集以及致病菌（如 或 ）和结合胆汁酸的消耗的变化，而红肉饮食诱导的致病菌（或 ）和结合胆汁酸的富集以及 SCFAs 和非结合胆汁酸的消耗的变化。
饮食中的白肉和红肉可能分别通过调节肠道微生物群及其代谢产物有利于和加重大鼠的 NAFLD。
