Laboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Copenhagen 2100, Denmark.
Laboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Copenhagen 2100, Denmark; Key Laboratory of Meat Processing and Quality Control, MOE, Key Laboratory of Meat Processing, MARA, Jiangsu Collaborative Innovation Centre of Meat Production and Processing, Quality and Safety Control, College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, PR China.
Food Chem. 2022 Dec 15;397:133769. doi: 10.1016/j.foodchem.2022.133769. Epub 2022 Jul 25.
Casein and meat are food sources providing high-quality animal proteins for human consumption. However, little is known concerning potentially different effects of these animal protein sources during early stages of life. In the present study, casein and red meat proteins (beef and pork) were fed to young postweaning rats for 14 days based on the AIN-93G diet formula. Casein and red meat protein-based diets did not differentially affect the overall growth performance. However, they discriminately modulated the abundances of different potentially beneficial bacteria belonging to genus Lactobacillus. Intake of the casein-based diet increased the intestinal abundance of Lactococcus lactis with a pronounced potential for galactose utilization via the Tag6P pathway, and it also resulted in lower amounts of toxic ammonia in the rat cecum compared to red meat protein-based diets. We observed no adverse effects on colonic tissue in response to any of the protein-based diets based on histological observations.
酪蛋白和肉类是为人类提供高质量动物蛋白的食物来源。然而，对于这些动物蛋白源在生命早期阶段可能产生的不同影响，人们知之甚少。在本研究中，基于 AIN-93G 饮食配方，将酪蛋白和红肉蛋白（牛肉和猪肉）喂给年轻的断奶后大鼠 14 天。酪蛋白和红肉蛋白饮食并没有对整体生长性能产生不同的影响，但它们对属于乳杆菌属的不同潜在有益细菌的丰度有差异调节作用。摄入基于酪蛋白的饮食增加了肠道中乳酸乳球菌的丰度，通过 Tag6P 途径具有明显的利用半乳糖的潜力，并且与基于红肉蛋白的饮食相比，大鼠盲肠中的有毒氨含量也较低。根据组织学观察，我们没有观察到任何蛋白质饮食对结肠组织的不良反应。
