Malik Ali O, Jones Philip G, Chan Paul S
Saint Luke's Mid America Heart Institute, Kansas City, MO, USA; University of Missouri Kansas City, MO, USA.
Am Heart J Plus. 2022 May;17. doi: 10.1016/j.ahjo.2022.100151. Epub 2022 Jun 11.
We assessed the association of acute exposure to ambient air particulate matter < 2.5 μm (PM) and Ozone with risk of out of hospital cardiac arrest (OHCA).
We used data from the Cardiac Arrest Registry to Enhance Survival (CARES), a prospective multicenter registry of patients with OHCA in the U.S. Environmental data was obtained from publicly available data and linked with each patient. A case-crossover design was used to estimate association of acute exposure to ambient air PM and Ozone with risk of OHCA. Case day was defined as the day of the OHCA, and control days were same days of the week from preceding two weeks.
Of 187,047 patients with OHCA, mean age was 61.5 ± 19.9 years, 59.7 % were males and 47.1 % were of White race. Mean daily PM concentration on case day was 9.2 ± 4.9 μg/m and mean averaged 8-hour Ozone concentration was 36.9 ± 12.1 ppb. Each 5 μg/m increase in PM concentration () was not associated with risk of OHCA (OR 0.99 [95 % CI 0.998, 1.017] p = 0.72). In contrast, there was an association of exposure to Ozone with risk of OHCA with every 12 ppb increase in Ozone associated with a higher risk for OHCA on case day (OR 1.011 [95 % CI 1.003, 1.019] p = 0.01).
In the U.S., higher exposure to Ozone was associated with increased risk of OHCA.
我们评估了急性暴露于环境空气中直径小于2.5微米的颗粒物（PM）和臭氧与院外心脏骤停（OHCA）风险之间的关联。
我们使用了心脏骤停登记以提高生存率（CARES）的数据，这是一个美国OHCA患者的前瞻性多中心登记。环境数据从公开可用数据中获取，并与每位患者相关联。采用病例交叉设计来估计急性暴露于环境空气中的PM和臭氧与OHCA风险之间的关联。病例日定义为OHCA发生日，对照日为前两周中相同的星期几。
在187,047例OHCA患者中，平均年龄为61.5±19.9岁，59.7%为男性，47.1%为白人。病例日的每日平均PM浓度为9.2±4.9微克/立方米，平均8小时臭氧浓度为36.9±12.1 ppb。PM浓度每增加5微克/立方米（）与OHCA风险无关（OR 0.99 [95% CI 0.998, 1.017] p = 0.72）。相比之下，臭氧暴露与OHCA风险有关，臭氧每增加12 ppb与病例日OHCA风险升高有关（OR 1.011 [95% CI 1.003, 1.019] p = 0.01）。
在美国，较高的臭氧暴露与OHCA风险增加有关。
