Manganas Phanee, Kavatzikidou Paraskevi, Kordas Antonis, Babaliari Eleftheria, Stratakis Emmanuel, Ranella Anthi
Tissue Engineering, Regenerative Medicine and Immunoengineering Laboratory, Institute of Electronic Structure and Laser, Foundation for Research and Technology-Hellas (IESL-FORTH), Heraklion, Greece.
Ultrafast Laser Micro and Nano Processing Laboratory, Institute of Electronic Structure and Laser, Foundation for Research and Technology-Hellas (IESL-FORTH), Heraklion, Greece.
Front Cell Neurosci. 2022 Aug 10;16:948454. doi: 10.3389/fncel.2022.948454. eCollection 2022.
Schwann cells (SCs), the glial cells of the peripheral nervous system (PNS), do not only form myelin sheaths thereby insulating the electrical signal propagated by the axons, but also play an essential role in the regeneration of injured axons. SCs are inextricably connected with their extracellular environment and the mechanical stimuli that are received determine their response during development, myelination and injuries. To this end, the mechanobiological response of SCs is being actively researched, as it can determine the suitability of fabricated scaffolds for tissue engineering and regenerative medicine applications. There is growing evidence that SCs are sensitive to changes in the mechanical properties of the surrounding environment (such as the type of material, its elasticity and stiffness), different topographical features provided by the environment, as well as shear stress. In this review, we explore how different mechanical stimuli affect SC behaviour and highlight the importance of exploring many different avenues when designing scaffolds for the repair of PNS injuries.
施万细胞（SCs）是周围神经系统（PNS）的神经胶质细胞，不仅形成髓鞘从而使轴突传播的电信号绝缘，而且在受损轴突的再生中也起着至关重要的作用。施万细胞与其细胞外环境紧密相连，所接收的机械刺激决定了它们在发育、髓鞘形成和损伤过程中的反应。为此，施万细胞的力学生物学反应正在被积极研究，因为它可以决定制造的支架在组织工程和再生医学应用中的适用性。越来越多的证据表明，施万细胞对周围环境的机械特性变化（如材料类型、弹性和硬度）、环境提供的不同地形特征以及剪切应力敏感。在这篇综述中，我们探讨了不同的机械刺激如何影响施万细胞的行为，并强调了在设计用于修复周围神经损伤的支架时探索多种不同途径的重要性。
