Yu James J, Non Amy L, Heinrich Erica C, Gu Wanjun, Alcock Joe, Moya Esteban A, Lawrence Elijah S, Tift Michael S, O'Brien Katie A, Storz Jay F, Signore Anthony V, Khudyakov Jane I, Milsom William K, Wilson Sean M, Beall Cynthia M, Villafuerte Francisco C, Stobdan Tsering, Julian Colleen G, Moore Lorna G, Fuster Mark M, Stokes Jennifer A, Milner Richard, West John B, Zhang Jiao, Shyy John Y, Childebayeva Ainash, Vázquez-Medina José Pablo, Pham Luu V, Mesarwi Omar A, Hall James E, Cheviron Zachary A, Sieker Jeremy, Blood Arlin B, Yuan Jason X, Scott Graham R, Rana Brinda K, Ponganis Paul J, Malhotra Atul, Powell Frank L, Simonson Tatum S
Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, United States.
Department of Anthropology, Division of Social Sciences, University of California, San Diego, La Jolla, CA, United States.
Front Physiol. 2022 Aug 8;13:885295. doi: 10.3389/fphys.2022.885295. eCollection 2022.
The ability to respond rapidly to changes in oxygen tension is critical for many forms of life. Challenges to oxygen homeostasis, specifically in the contexts of evolutionary biology and biomedicine, provide important insights into mechanisms of hypoxia adaptation and tolerance. Here we synthesize findings across varying time domains of hypoxia in terms of oxygen delivery, ranging from early animal to modern human evolution and examine the potential impacts of environmental and clinical challenges through emerging multi-omics approaches. We discuss how diverse animal species have adapted to hypoxic environments, how humans vary in their responses to hypoxia (i.e., in the context of high-altitude exposure, cardiopulmonary disease, and sleep apnea), and how findings from each of these fields inform the other and lead to promising new directions in basic and clinical hypoxia research.
对氧张力变化做出快速反应的能力对多种生命形式至关重要。氧稳态面临的挑战，特别是在进化生物学和生物医学背景下，为缺氧适应和耐受机制提供了重要见解。在这里，我们综合了从早期动物到现代人类进化过程中不同时间域内缺氧时氧输送方面的研究结果，并通过新兴的多组学方法研究环境和临床挑战的潜在影响。我们讨论了不同动物物种如何适应低氧环境，人类对缺氧的反应如何不同（即在高原暴露、心肺疾病和睡眠呼吸暂停的背景下），以及这些领域的研究结果如何相互启发，并为基础和临床缺氧研究带来有前景的新方向。
