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COVID-19大流行应对:大型研究与教学机构的生物安全视角

The COVID-19 Pandemic Response: Biosafety Perspectives from a Large Research and Teaching Institution.

作者信息

Gillum David R, Rice Amanda D, Mendoza Irene A

机构信息

Environmental Health and Safety, Arizona State University, Tempe, Arizona, USA.

出版信息

Appl Biosaf. 2022 Jun 1;27(2):64-78. doi: 10.1089/apb.2022.0001. Epub 2022 May 27.

Abstract

INTRODUCTION

Although the COVID-19 pandemic began over 2 years ago, responses from institutions have not been thoroughly documented. Because of constantly evolving guidance from regulatory and public health agencies, the traditional evidence-based risk assessment process was disrupted. It took time to obtain enough actionable information about the novel SARS-CoV-2 virus and its transmission to be able to inform decision making and consistently make accurate recommendations.

OBJECTIVES

The primary objective of this article is to detail the actions in chronological order taken by the biosafety team at Arizona State University in response to the COVID-19 pandemic.

METHODS

This article includes a chronicling of actual experiences and observations with a retrospective review and analysis of the actions taken to document and share lessons learned to guard against future pandemics. Specific infection control practices, such as measuring saliva droplets from dropped test tubes, are described and different COVID-19 testing and vaccination site designs are evaluated.

RESULTS

The biosafety team helped collect more than 304,000 saliva samples, deliver 15,528 vaccinations, safely manage more than 170,000 gallons of biohazardous waste, and oversee the pandemic response inventory. The team also conducted inspections, developed safety procedures, and reviewed research protocols.

CONCLUSIONS

The COVID-19 pandemic required safety professionals to re-envision how they perform their work, not only at their place of employment, but also within their communities and at their homes. This presented a challenge to balance inquiry and the scientific process against the urgent need for understanding changing pandemic dynamics and information and developing new best practices.

摘要

引言

尽管新冠疫情始于两年多前,但各机构的应对措施尚未得到全面记录。由于监管机构和公共卫生机构的指导意见不断变化,传统的循证风险评估过程受到了干扰。获取关于新型严重急性呼吸综合征冠状病毒2(SARS-CoV-2)病毒及其传播的足够可操作信息,并据此为决策提供依据并持续做出准确建议,需要时间。

目的

本文的主要目的是按时间顺序详细介绍亚利桑那州立大学生物安全团队针对新冠疫情采取的行动。

方法

本文包括对实际经历和观察的记录,并对为记录和分享经验教训以防范未来疫情而采取的行动进行回顾性分析。描述了具体的感染控制措施,如测量从掉落试管中溅出的唾液飞沫,并评估了不同的新冠病毒检测和疫苗接种点设计。

结果

生物安全团队协助收集了超过30.4万份唾液样本,提供了15528次疫苗接种,安全管理了超过17万加仑的生物危险废物,并监督疫情应对物资库存。该团队还进行了检查,制定了安全程序,并审查了研究方案。

结论

新冠疫情要求安全专业人员重新设想他们的工作方式,不仅要在工作场所,还要在社区和家庭中。这带来了一个挑战,即要在进行调查和科学过程与迫切需要了解不断变化的疫情动态和信息以及制定新的最佳实践之间取得平衡。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4265/9150129/6f8557e67a42/apb.2022.0001_figure1.jpg

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