Wiester M J, Williams T B, King M E, Ménache M G, Miller F J
Toxicol Appl Pharmacol. 1987 Jul;89(3):429-37. doi: 10.1016/0041-008x(87)90162-1.
Knowledge of ozone (O3) uptake in rats in integral to efforts to quantitatively extrapolate animal data to man. We have measured percentage O3 uptake in 30 adult Sprague-Dawley rats exposed, nose only, for 1 hr to 0.3, 0.6, or 1.0 ppm O3. Tidal volume and breathing rate measurements, obtained by plethysmography, were time-matched with changes in airstream concentrations of O3, oxygen, and carbon dioxide, due to animal breathing, for computation of O3 uptake and respiratory gas exchange values. Ozone uptake was calculated by a fractional deposition technique, i.e. O3 in vs O3 out. Total respiratory system O3 uptake was found to be approximately 40% of that inspired and did not vary with O3 concentration nor during the 1-hr exposure. The quantity of O3 inhaled and retained by the rat increased proportionally with O3 concentration.
了解大鼠对臭氧（O₃）的摄取情况对于将动物数据定量外推至人类的研究工作至关重要。我们测量了30只成年Sprague-Dawley大鼠仅通过鼻腔暴露于0.3、0.6或1.0 ppm O₃环境中1小时后的O₃摄取百分比。通过体积描记法获得的潮气量和呼吸频率测量值与因动物呼吸导致的气流中O₃、氧气和二氧化碳浓度变化进行了时间匹配，以计算O₃摄取量和呼吸气体交换值。O₃摄取量通过分数沉积技术计算，即吸入的O₃与呼出的O₃之比。发现整个呼吸系统的O₃摄取量约为吸入量的40%，且不随O₃浓度变化，在1小时的暴露期间也无变化。大鼠吸入并留存的O₃量随O₃浓度成比例增加。
