Miller F J, McNeal C A, Kirtz J M, Gardner D E, Coffin D L, Menzel D B
Toxicology. 1979 Nov;14(3):273-81. doi: 10.1016/0300-483x(79)90009-x.
In estimating pollutant concentrations responsible for observed pulmonary effects, nasopharyngeal removal of the pollutant plays an important role. The nasopharyngeal removal of ozone (O3) in anesthetized male guinea pigs and male and female rabbits was determined by drawing O3 through the isolated upper airways at a constant flow rate which approximated the animal's respiratory minute volume. The tracheal O3 concentration in rabbits and guinea pigs was markedly similar and was linearly related to the chamber concentration of O3 over a range of 196--3920 micrograms/m3 (0.1--2.0 ppm O3). Regression analyses showed that O3 removal in the nasopharyngeal region is approximately 50% in both species. Both rabbit sexes responded similarly over the concentration range studied. Exposures of guinea pigs to O3 concentrations between 3920 and 5880 micrograms/m3 (2.0 and 3.0 ppm) showed that, at these higher concentrations, relatively more O3 is removed by the upper airways.
在估算导致所观察到的肺部效应的污染物浓度时，污染物在鼻咽部的清除起着重要作用。通过以接近动物呼吸分钟通气量的恒定流速将臭氧（O₃）通入离体上呼吸道，测定了麻醉的雄性豚鼠以及雄性和雌性兔子的鼻咽部对臭氧的清除情况。在196 - 3920微克/立方米（0.1 - 2.0 ppm O₃）的范围内，兔子和豚鼠气管中的O₃浓度显著相似，并且与腔室中的O₃浓度呈线性关系。回归分析表明，在这两个物种中，鼻咽部对O₃的清除率约为50%。在所研究的浓度范围内，两种性别的兔子反应相似。豚鼠暴露于3920至5880微克/立方米（2.0至3.0 ppm）的O₃浓度下，结果表明，在这些较高浓度下，上呼吸道对O₃的清除相对更多。
