Department of Orthopaedic Surgery, University of Missouri - Columbia School of Medicine.
Thompson Laboratory for Regenerative Orthopaedics, University of Missouri - Columbia, Columbia, Missouri.
Mo Med. 2022 Mar-Apr;119(2):129-135.
Despite the surgical advances in treatment of peripheral nerve injuries, consistent recovery of function is limited suggesting that a multimodal approach is required to optimize nerve regeneration. This approach should include advanced surgical repair techniques, as well as tissue engineering, cellular therapies, and application of local and systemic modulators of neuroregeneration. Further research is needed to advance these therapies from the laboratory to clinical practice, and to further understand how these treatments and techniques can act in concert to optimize functional nerve regeneration.
尽管在外周神经损伤的治疗方面已经取得了外科手术的进展,但功能的持续恢复仍然受到限制,这表明需要采用多模式方法来优化神经再生。这种方法应包括先进的手术修复技术,以及组织工程、细胞疗法和应用局部和全身神经再生调节剂。需要进一步的研究将这些疗法从实验室推进到临床实践,并进一步了解这些治疗方法和技术如何协同作用以优化功能性神经再生。