Yu Zi-Wei, Lu Meng-Jiang, Yu Zhi, Xu Bin
Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Zhen Ci Yan Jiu. 2022 Aug 25;47(8):744-8. doi: 10.13702/j.1000-0607.20210530.
The physiological function of adipose tissue is dominated by the sympathetic nerve system (SNS), but obesity and other diseases may cause the abnormality of the SNS signaling pathway. Acupuncture has been proved to be an effective the-rapy to improve the function of SNS in adipose tissue. Based on the physiological and pathological significance of SNS, this paper reviewed the molecular pathways in which acupuncture directly or indirectly regulated the function of SNS in adipose tissue. As the mechanism of electroacupuncture in regulating autonomic nerves was continuously illuminated, the adjustment of acupuncture mode, such as selection of acupoints in different nerve segments and adjustment of stimulation parameters of electroacupuncture, presumedly induced different content ratios of neurotransmitters released by SNS efferent axons, including noradrenaline and neuropeptide Y, thereby producing different effects on weight loss. Therefore, the specific connections between various acupuncture modes and neurotransmitters released by SNS enriched the intrinsic nerve coding of acupoints, thus optimizing the acupoint selection protocol for the treatment of obesity.
脂肪组织的生理功能受交感神经系统（SNS）支配，但肥胖及其他疾病可能导致SNS信号通路异常。针灸已被证明是改善脂肪组织中SNS功能的有效疗法。基于SNS的生理和病理意义，本文综述了针灸直接或间接调节脂肪组织中SNS功能的分子途径。随着电针调节自主神经机制的不断阐明，针灸模式的调整，如不同神经节段穴位的选择及电针刺激参数的调整，可能诱导SNS传出轴突释放的神经递质（包括去甲肾上腺素和神经肽Y）产生不同的含量比例，进而对减肥产生不同效果。因此，各种针灸模式与SNS释放的神经递质之间的特定联系丰富了穴位的内在神经编码，从而优化了肥胖治疗的选穴方案。
