儿童过敏性紫癜中降解单糖的血清水平。
Serum levels of degraded monosaccharides in children with Henoch-Schönlein purpura.
机构信息
Department of Pediatric Nephrology and Rheumatology, Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, China.
出版信息
Zhongguo Dang Dai Er Ke Za Zhi. 2022 Aug 15;24(8):894-898. doi: 10.7499/j.issn.1008-8830.2202125.
OBJECTIVES
To examine the serum levels of degraded monosaccharides in children with Henoch-Schönlein purpura (HSP) and to study the clinical significance of degraded monosaccharides in HSP.
METHODS
A prospective analysis was performed on 132 children who were diagnosed with HSP from September 2019 to January 2022, and 132 healthy children were enrolled as the control group. High-performance liquid chromatography was used to determine the content of degraded monosaccharides in serum in both groups. The receiver operating characteristic (ROC) curve was used to evaluate the efficiency of degraded monosaccharides for the diagnosis of HSP.
RESULTS
Compared with the control group, the HSP group had significantly higher serum levels of mannose, glucosamine, aminogalactose, and galactose (<0.001). The four degraded monosaccharides had an area under the ROC curve of 0.919, 0.913, 0.832, and 0.932 respectively for the diagnosis of HSP (<0.05).
CONCLUSIONS
Children with HSP have higher serum levels of mannose, glucosamine, aminogalactose, and galactose than the healthy population. The levels of degraded monosaccharides may have an important value for the diagnosis of HSP.
目的
检测儿童过敏性紫癜（HSP）患者血清中降解单糖的水平，并研究 HSP 中降解单糖的临床意义。
方法
前瞻性分析了 2019 年 9 月至 2022 年 1 月期间诊断为 HSP 的 132 例患儿，并纳入 132 例健康儿童作为对照组。采用高效液相色谱法测定两组血清中降解单糖的含量。受试者工作特征（ROC）曲线评估降解单糖对 HSP 诊断的效率。
结果
与对照组相比，HSP 组患儿血清中的甘露糖、氨基葡萄糖、氨基半乳糖和半乳糖水平显著升高（<0.001）。四种降解单糖用于诊断 HSP 的 ROC 曲线下面积分别为 0.919、0.913、0.832 和 0.932（<0.05）。
结论
HSP 患儿血清中甘露糖、氨基葡萄糖、氨基半乳糖和半乳糖水平高于健康人群。降解单糖的水平可能对 HSP 的诊断具有重要价值。
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