Kang Zhi-Juan, Liu Bo, Li Zhi-Hui, Duan Cui-Rong, Wu Tian-Hui, Xun Man, Zhang Yi, Ding Yun-Feng, Fu Ru-Qian
Department of Nephrology and Rheumatology, Hunan Children's Hospital/Academy of Pediatrics of University of South China, Changsha 410007, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2019 Feb;21(2):172-175. doi: 10.7499/j.issn.1008-8830.2019.02.013.
To explore the value of galactose-deficient IgA1 (Gd-IgA1) in the early diagnosis of Henoch-Schönlein purpura nephritis (HSPN) in children.
A total of 67 hospitalized children who were definitely diagnosed with HSPN between January and April 2018 and 58 hospitalized children with Henoch-Schönlein purpura (HSP) were enrolled in the study. Twenty children undergoing routine physical examinations served as controls. The levels of serum and urine Gd-IgA1 were determined using ELISA. The receiver operating characteristic curve was used to analyze the value of serum Gd-IgA1 and urine Gd-IgA1/urine creatinine ratio in the diagnosis of HSPN.
The level of serum Gd-IgA1 and urine Gd-IgA1/urine creatinine ratio in children with HSP or HSPN were significantly higher than those in healthy control group (P<0.01), with a significantly greater increase observed in children with HSPN (P<0.01). Serum Gd-IgA1 ≥1 485.57 U/mL and/or urine Gd-IgA1/urine creatinine ratio ≥105.74 were of favorable value in the diagnosis of HSPN. During the six-month follow-up of the 49 children with HSP, the incidence of HSPN was 47% (23/49), which included a 100% incidence in children with serum Gd-IgA1 ≥1 485.57 U/mL and a 73% incidence in children with urine Gd-IgA1/urine creatinine ratio ≥105.74.
Serum and urine Gd-IgA1 is of favorable clinical value in the early diagnosis of HSPN.
探讨去半乳糖IgA1（Gd-IgA1）在儿童过敏性紫癜性肾炎（HSPN）早期诊断中的价值。
选取2018年1月至4月期间确诊为HSPN的67例住院患儿以及58例过敏性紫癜（HSP）住院患儿作为研究对象。选取20例接受常规体检的儿童作为对照组。采用酶联免疫吸附测定法（ELISA）检测血清和尿液Gd-IgA1水平。采用受试者工作特征曲线分析血清Gd-IgA1和尿液Gd-IgA1/尿肌酐比值在HSPN诊断中的价值。
HSP或HSPN患儿的血清Gd-IgA1水平及尿液Gd-IgA1/尿肌酐比值均显著高于健康对照组（P<0.01），HSPN患儿升高更为明显（P<0.01）。血清Gd-IgA1≥1485.57 U/mL和/或尿液Gd-IgA1/尿肌酐比值≥105.74对HSPN诊断具有良好价值。对49例HSP患儿进行6个月随访，HSPN发生率为47%（23/49），其中血清Gd-IgA1≥1485.57 U/mL的患儿HSPN发生率为100%，尿液Gd-IgA1/尿肌酐比值≥105.74的患儿HSPN发生率为73%。
血清和尿液Gd-IgA1在HSPN早期诊断中具有良好的临床价值。
