Elkins D B, Haswell-Elkins M, Anderson R M
Trans R Soc Trop Med Hyg. 1986;80(5):774-92. doi: 10.1016/0035-9203(86)90384-6.
The study design of a project to investigate the epidemiology, population dynamics and control of intestinal nematode infections in fishing village communities in Southern India is described. The paper focuses on Ascaris lumbricoides infection and describes changes in prevalence and intensity (worm burdens) with host age, the aggregated frequency distributions of parasite numbers per person, a density-dependent relationship between parasite fecundity and worm burden and rates of reinfection following chemotherapeutic treatment. The age-intensity of infection profile is convex in form, where maximum worm burdens are attained in children in the age range five to nine years. On the basis of juvenile to adult worm ratioos, the life expectancy of Ascaris in man is estimated to be of the order of one year. Rates of reacquisition of worms after chemotherapy are shown to be dependent on host age. Wormy individuals with heavy infections are shown to be predisposed to this state such that they reacquire heavier than average worm burdens following treatment.
本文描述了一项关于印度南部渔村社区肠道线虫感染的流行病学、种群动态及控制的项目研究设计。该论文聚焦于蛔虫感染，并描述了感染率和感染强度（虫负荷）随宿主年龄的变化、每人寄生虫数量的聚集频率分布、寄生虫繁殖力与虫负荷之间的密度依赖关系以及化疗后再感染率。感染强度随年龄变化的曲线呈凸形，其中5至9岁儿童的虫负荷最大。根据幼虫与成虫的比例，估计人体内蛔虫的寿命约为一年。化疗后蠕虫重新感染的速率取决于宿主年龄。感染严重的个体易处于这种状态，以至于治疗后他们重新获得的虫负荷比平均水平更重。
