Croll N A, Anderson R M, Gyorkos T W, Ghadirian E
Trans R Soc Trop Med Hyg. 1982;76(2):187-97. doi: 10.1016/0035-9203(82)90272-3.
Adults of Ascaris lumbricoides were recovered from 252 persons in the village of Jazin near Esfahan, Iran after treatment with pyrantel pamoate. This horizontal study provides information on age-specific prevalence rates, intensities of infection, frequency distributions, sex ratios and eggs per gram of stool at different parasite intensities. Recruitment of A. lumbricoides was then monitored at 7, 30, 60, 90 and 365 days after treatment in 110 persons. A separate sample population was examined at monthly intervals and, in addition, the stool of each member of a nine-person family was examined for 10 consecutive days. These data are analysed and used to describe the dynamics of transmissions and recruitment of A. lumbricoides in Jazin. The population dynamics of ascariasis are discussed in the context of R the basic reproductive rate of the parasite. The relationships of R with frequency distributions, prevalencies and worm burdens are discussed. Because of the considerable potential of A. lumbricoides to re-infect man in endemic areas, it is shown that it will be difficult to eradicate ascariasis by the use of chemotherapy, even when drugs with a high efficacy are used repeatedly.
在伊朗伊斯法罕附近的贾津村，252人在接受双羟萘酸噻嘧啶治疗后排出了蛔虫成虫。这项横向研究提供了不同年龄组的患病率、感染强度、频率分布、性别比以及不同寄生虫感染强度下每克粪便中的虫卵数等信息。随后，对110人在治疗后第7天、30天、60天、90天和365天进行了蛔虫再感染监测。另外选取了一个样本群体每月进行检查，并且对一个九口之家的每个成员的粪便连续检查10天。对这些数据进行分析，以描述贾津村蛔虫传播和再感染的动态情况。在寄生虫的基本繁殖率R的背景下讨论了蛔虫病的种群动态。讨论了R与频率分布、患病率和虫负荷的关系。由于蛔虫在流行地区使人再次感染的潜力很大，研究表明，即使反复使用高效药物，通过化疗根除蛔虫病也将很困难。
