Steel Cindy, Wile Heather, Li Olivia, Yedulla Swapna, Hare Ian, Hopkins Bethany
Nestlé Health Science Canada, North York, Ontario, Canada.
Clarivate Data Analytics & Insights, Toronto, Ontario, Canada.
Nutr Clin Pract. 2023 Apr;38(2):449-457. doi: 10.1002/ncp.10905. Epub 2022 Aug 29.
Home enteral nutrition (HEN) is frequently prescribed to individuals who cannot consume adequate food orally. Commercial blenderized enteral formulas (CBEF) containing real-food ingredients are becoming more popular and more widely available; however, the demographics of patients receiving these formulas have rarely been evaluated, and little data are available on patient tolerance in the community.
US claims data were obtained for children and adolescents/adults who used the CBEF of interest as the sole source of nutrition via enteral feeding tube in the community setting following discharge from acute care. Demographics, concomitant medications, clinical diagnoses, and Charlson Comorbidity Index scores were tabulated using descriptive statistics. Gastrointestinal (GI) symptoms before and after hospital discharge were compared using significance tests.
The study included 231 participants (180 children, 51 adolescents/adults). CBEFs were prescribed to patients with a variety of diagnoses, of which the most common were digestive and respiratory disorders. Children experienced significantly lower rates of diarrhea, nausea, vomiting, constipation, and abdominal distension in the weeks following hospital discharge compared with the baseline (all P < 0.001). Adolescents/adults experienced significantly lower rates of constipation, nausea, and vomiting (all P < 0.05). Neither group increased their usage of GI medications following hospital discharge.
These CBEFs, based on real-food ingredients, were prescribed to diverse patients in the community and were well tolerated. These formulas offer an alternative to standard polymeric formulas and an alternative or adjunct to homemade blenderized formulas.
家庭肠内营养（HEN）常用于无法经口摄入足够食物的个体。含有真实食物成分的商业搅拌型肠内配方（CBEF）越来越受欢迎且更容易获得；然而，接受这些配方的患者人口统计学特征很少被评估，且关于社区患者耐受性的数据也很少。
获取美国急性护理出院后在社区环境中通过肠内喂养管将感兴趣的CBEF作为唯一营养来源的儿童和青少年/成人的理赔数据。使用描述性统计对人口统计学、伴随用药、临床诊断和查尔森合并症指数评分进行列表分析。使用显著性检验比较出院前后的胃肠道（GI）症状。
该研究纳入了231名参与者（180名儿童，51名青少年/成人）。CBEF被开给各种诊断的患者，其中最常见的是消化和呼吸系统疾病。与基线相比，儿童出院后几周腹泻、恶心、呕吐、便秘和腹胀的发生率显著降低（所有P<0.001）。青少年/成人便秘、恶心和呕吐的发生率显著降低（所有P<0.05）。两组出院后均未增加胃肠道药物的使用。
这些基于真实食物成分的CBEF在社区中被开给不同的患者，且耐受性良好。这些配方为标准聚合物配方提供了替代方案，也为自制搅拌型配方提供了替代方案或辅助方案。
