Department of Periodontology, Nihon University School of Dentistry, Tokyo.
Dental Research Center, Nihon University School of Dentistry, Tokyo, Japan.
J Int Med Res. 2022 Aug;50(8):3000605221117148. doi: 10.1177/03000605221117148.
Periodontal inflammation is associated with systemic disease. Low-grade inflammation (LGI) is critical to the link between periodontal disease and several systemic disorders. C-reactive protein (CRP) is a common circulating biomarker for acute-phase immune responses, and it is closely related to LGI. The present case demonstrated excellent results using a comprehensive approach for periodontitis in a young woman with severe periodontitis and mild CRP elevation. A 21-year-old Japanese woman complained of tooth mobility and bleeding during tooth brushing. She was pre-obese (body mass index = 29.9), and she had a mildly elevated CRP level (5.2 mg/L). Of all periodontal sites, 34.5% had deep pockets (≥6 mm). The patient was diagnosed with stage III, grade C periodontitis and generalized aggressive periodontitis. Comprehensive periodontal treatments, including regenerative procedures for vertical bone loss and furcation involvement, were performed. Periodontal tissue inflammation was resolved, and periodontal regeneration was achieved. During the 2-year follow-up period, her teeth did not exhibit any signs of instability, attachment loss, or bone loss. Despite the weak nature of the evidence, this case suggests that CRP is valuable for assessing LGI, and it may potentially be considered during periodontal grading in the future.
牙周炎与全身性疾病有关。低度炎症（LGI）是牙周病与多种全身性疾病之间关联的关键。C 反应蛋白（CRP）是急性免疫反应的常见循环生物标志物，与 LGI 密切相关。本病例通过综合方法治疗了一名年轻女性严重的牙周炎和轻度 CRP 升高的牙周炎，取得了极好的效果。一名 21 岁的日本女性因刷牙时牙齿松动和出血而就诊。她为超重（体重指数=29.9），且 CRP 水平轻度升高（5.2mg/L）。所有牙周部位中，有 34.5%的牙周袋深度≥6mm。该患者被诊断为牙周炎 III 期 C 级和广泛性侵袭性牙周炎。对其进行了全面的牙周治疗，包括垂直骨缺损和分叉区受累的再生治疗。牙周组织炎症得到缓解，牙周再生成功。在 2 年的随访期间，她的牙齿没有出现任何不稳定、附着丧失或骨丧失的迹象。尽管证据强度较弱，但该病例提示 CRP 可用于评估 LGI，未来在牙周病分级时可能会考虑这一点。
