Private practice, Takayama Dental Clinic, Shiga, Japan.
Department of Periodontology, Graduate School of Dentistry, Osaka University, Osaka, Japan.
Clin Adv Periodontics. 2021 Jun;11(2):74-79. doi: 10.1002/cap.10127. Epub 2020 Nov 3.
Several studies have demonstrated that basic fibroblast growth factor (FGF-2) is one of the most effective growth factors for periodontal regeneration. The Ministry of Health, Labor and Welfare in Japan have approved 0.3% human recombinant FGF-2 for periodontal regeneration, and it has been commercially available since 2016. In this case report, a patient was treated with this periodontal regenerative medicine and demonstrated success at 15-month follow-up, as confirmed by dental X-ray and on cone-beam computed tomography (CBCT).
A 42-year-old woman with a one by two walled intrabony defect and Class III furcation involvement in tooth #19, and Class II furcation involvement in tooth #18 (lingual) underwent periodontal regenerative surgery with FGF-2 without any bone graft materials. Favorable clinical and radiographic outcomes were noted 15 months after the procedure. The vertical bone defect in tooth #19 showed a clinical attachment level gain of 8 mm. Moreover, CBCT analysis revealed considerable new bone formation in the Class II furcation involvement in tooth #18 and limited bone formation in the Class III furcation involvement in tooth #19.
This case report indicates that FGF-2 showed a positive outcome in terms of periodontal regeneration in a case of one by two wall intrabony defects with Class III furcation involvement. A complete recovery of Class II furcation involvement was observed without artificial bone graft materials.
多项研究表明，碱性成纤维细胞生长因子（FGF-2）是促进牙周组织再生最有效的生长因子之一。日本厚生劳动省批准了 0.3%人重组 FGF-2 用于牙周组织再生，该药物自 2016 年起已上市销售。在本病例报告中，一位患者接受了这种牙周再生药物治疗，15 个月的随访结果显示成功，通过牙科 X 线和锥形束 CT（CBCT）得到了证实。
一位 42 岁女性，19 号牙存在 1 壁 2 壁的骨内缺损，伴有 III 度分叉区受累；18 号牙（舌侧）存在 II 度分叉区受累，接受了 FGF-2 牙周再生手术，未使用任何骨移植材料。术后 15 个月，临床和影像学结果均良好。19 号牙的垂直骨缺损临床附着水平增加了 8mm。此外，CBCT 分析显示 18 号牙 II 度分叉区受累处有大量新骨形成，19 号牙 III 度分叉区受累处有有限的骨形成。
本病例报告表明，FGF-2 在 1 壁 2 壁骨内缺损伴 III 度分叉区受累的病例中，具有积极的牙周组织再生效果。在不使用人工骨移植材料的情况下，观察到 II 度分叉区受累完全恢复。
