Kocaeli Derince Education and Research Hospital Ophthalmology Department , Lojman Sk İbni Sina, 41900, Derince, , Kocaeli, Turkey.
Int Ophthalmol. 2023 Mar;43(3):749-756. doi: 10.1007/s10792-022-02474-4. Epub 2022 Aug 29.
To compare serum 25-hydroxyvitamin D (25(OH)D) levels of patients with dermatochalasis who underwent upper lid blepharoplasty and healthy controls.
This retrospective comparative study included dermatochalasis patients who underwent upper lid blepharoplasty and age-and sex-matched controls from January 2019 to January 2021. The data, including comprehensive ophthalmological examination, internal medicine outpatient examination, and laboratory results of the dermatochalasis patients and healthy controls, were collected from the electronic patient records. Serum 25(OH)D, creatinine, calcium (Ca), phosphate (P), triglyceride (TG), low-density lipoprotein (LDL), and high-density lipoprotein (HDL) levels were evaluated and compared between the dermatochalasis patients and healthy controls.
Of our participants, consisting of 46 patients with dermatochalasis and 52 healthy controls, 54 (55.10%) were female and 44 (44.90%) were male. A statistically significant difference was observed in vitamin D levels between the healthy and dermatochalasis groups (p ≤ 0.001). The percentage of individuals with vitamin D deficiency (< 20 ng/mL) was significantly higher in the dermatochalasis group (p = 0.001). In addition, the percentage of individuals with severe vitamin D deficiency (< 10 ng/mL) was again significantly higher in the dermatochalasis group (p = 0.001). The risk of dermatochalasis incidence was found to increase in cases of low vitamin D (OR = 1.210; p = 0.017).
Low serum 25(OH)D levels may play a role in the etiopathogenesis of dermatochalasis. Future research should include longitudinal studies and prospective clinical studies to investigate the mechanism responsible for the low vitamin D observed in dermatochalasis patients.
比较行上睑成形术的皮肤松弛症患者和健康对照者的血清 25-羟维生素 D（25（OH）D）水平。
本回顾性对照研究纳入了 2019 年 1 月至 2021 年 1 月期间行上睑成形术的皮肤松弛症患者和年龄及性别匹配的健康对照者。从电子病历中收集了皮肤松弛症患者和健康对照者的全面眼科检查、内科门诊检查和实验室结果等数据。评估并比较了皮肤松弛症患者和健康对照者的血清 25（OH）D、肌酐、钙（Ca）、磷（P）、甘油三酯（TG）、低密度脂蛋白（LDL）和高密度脂蛋白（HDL）水平。
在我们的参与者中，包括 46 名皮肤松弛症患者和 52 名健康对照者，54 名（55.10%）为女性，44 名（44.90%）为男性。健康组和皮肤松弛症组的维生素 D 水平存在统计学显著差异（p≤0.001）。皮肤松弛症组维生素 D 缺乏（<20 ng/mL）的比例明显更高（p=0.001）。此外，皮肤松弛症组严重维生素 D 缺乏（<10 ng/mL）的比例再次明显更高（p=0.001）。维生素 D 水平低的情况下，皮肤松弛症的发病风险增加（OR=1.210；p=0.017）。
低血清 25（OH）D 水平可能在皮肤松弛症的发病机制中起作用。未来的研究应包括纵向研究和前瞻性临床研究，以研究皮肤松弛症患者中观察到的低维生素 D 的机制。
