State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Haihe Laboratory of Sustainable Chemical Transformations, Nankai University, Tianjin, 300071, China.
Luoyang Institute of Science and Technology, Luoyang, Henan Province, 471023, China.
Angew Chem Int Ed Engl. 2022 Oct 17;61(42):e202209625. doi: 10.1002/anie.202209625. Epub 2022 Sep 12.
Enantioselective Ni-catalyzed C(sp )-H bond activation remains an elusive challenge. Herein, we used phosphine oxide-ligated Ni-Al bimetallic catalyst to realize enantioselective Ni-catalyzed aliphatic C(sp )-H activation of formamides, providing a series of chiral N-containing heterocycles in 40-95 % yield and 70-95 % ee.
对映选择性镍催化 C(sp )-H 键活化仍然是一个难以捉摸的挑战。在此，我们使用磷氧化物配体的 Ni-Al 双金属催化剂实现了酰胺的对映选择性镍催化脂肪族 C(sp )-H 活化，以 40-95%的产率和 70-95%的对映选择性得到了一系列手性含氮杂环。
