State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Frontiers Science Center for New Organic Matter, Tianjin 300071, China.
Haihe Laboratory of Sustainable Chemical Transformations, Tianjin 300192, China.
Molecules. 2023 Jan 11;28(2):736. doi: 10.3390/molecules28020736.
Ligands play a critical role in promoting transition-metal-catalyzed C-H activation reactions. However, owing to high sensitivity of the reactivity of C-H activation to metal catalysts, the development of effective ligands has been a formidable challenge in the field. Rh(I)-catalyzed C-H cyclization of benzimidazoles with alkenes has been faced with low reactivity, often requiring very harsh conditions. To address this challenge, a phosphine oxide-enabled Rh(I)-Al bimetallic catalyst was developed for the reaction, significantly promoting the reactivity and allowing the reaction to run at 120 °C with up to 97% yield.
配体在促进过渡金属催化的 C-H 活化反应中起着关键作用。然而，由于 C-H 活化的反应性对金属催化剂非常敏感，因此开发有效的配体一直是该领域的一个巨大挑战。铑（I）催化的苯并咪唑与烯烃的 C-H 环化反应活性较低，通常需要非常苛刻的条件。为了解决这一挑战，开发了一种磷氧化物辅助的 Rh（I）-Al 双金属催化剂用于该反应，显著提高了反应活性，使反应在 120°C 下进行，产率高达 97%。
