Xu Panyang, He Bing, Zhou Qi, Xu Jiancheng
Department of Laboratory Medicine, First Hospital of Jilin University, Changchun, China.
Department of Pediatrics, First Hospital of Jilin University, Changchun, China.
Scand J Clin Lab Invest. 2022 Aug 29:1-6. doi: 10.1080/00365513.2021.1952485-1.
This study aimed to establish age- and sex-specific reference intervals for serum amylase and lipase in children by prospective investigation. A total of 6466 healthy Han children of 1 month ∼ <18 years were recruited in communities and schools in five administrative regions of Jilin Province, China. The serum amylase and lipase concentrations were measured on the VITROS 5600 integrated system. The reference intervals were defined by a nonparametric 95% percentile interval. Reference intervals of amylase were divided into four age-specific partitions. It increased rapidly between the ages of 1 month ∼ <1 year and 1 ∼ <5 years, slightly decreased between the ages of 5 ∼ <12 years, and increased slowly between 12 ∼ <18 years. Lipase concentrations showed sex differences after 1-year-old, with reference intervals in males divided into 2 divisions and 3 divisions in females. The lipase concentrations in both males and females showed an upward trend, and the lipase concentrations in females were higher than those in males. This study established reference intervals for amylase and lipase in healthy Chinese children and provided a more accurate explanation for the diagnosis and prognosis of clinical pediatric diseases.
本研究旨在通过前瞻性调查建立儿童血清淀粉酶和脂肪酶的年龄及性别特异性参考区间。在中国吉林省五个行政区的社区和学校招募了6466名1个月至<18岁的健康汉族儿童。在VITROS 5600综合系统上测定血清淀粉酶和脂肪酶浓度。参考区间由非参数95%百分位数区间定义。淀粉酶的参考区间分为四个年龄特异性分区。在1个月至<1岁和1至<5岁之间迅速升高，在5至<12岁之间略有下降，在12至<18岁之间缓慢升高。1岁后脂肪酶浓度存在性别差异，男性参考区间分为2个分区，女性分为3个分区。男性和女性的脂肪酶浓度均呈上升趋势且女性脂肪酶浓度高于男性。本研究建立了健康中国儿童淀粉酶和脂肪酶的参考区间，为临床儿科疾病的诊断和预后提供了更准确的依据。
