Department of Laboratory Medicine, First Hospital of Jilin University, Changchun, China.
Department of Pediatrics, First Hospital of Jilin University, Changchun, China.
Scand J Clin Lab Invest. 2021 Oct;81(6):502-507. doi: 10.1080/00365513.2021.1952485. Epub 2021 Jul 29.
This study aimed to establish age- and sex-specific reference intervals for serum amylase and lipase in children by prospective investigation. A total of 6466 healthy Han children of 1 month ∼ <18 years were recruited in communities and schools in five administrative regions of Jilin Province, China. The serum amylase and lipase concentrations were measured on the VITROS 5600 integrated system. The reference intervals were defined by a nonparametric 95% percentile interval. Reference intervals of amylase were divided into four age-specific partitions. It increased rapidly between the ages of 1 month ∼ <1 year and 1 ∼ <5 years, slightly decreased between the ages of 5 ∼ <12 years, and increased slowly between 12 ∼ <18 years. Lipase concentrations showed sex differences after 1-year-old, with reference intervals in males divided into 2 divisions and 3 divisions in females. The lipase concentrations in both males and females showed an upward trend, and the lipase concentrations in females were higher than those in males. This study established reference intervals for amylase and lipase in healthy Chinese children and provided a more accurate explanation for the diagnosis and prognosis of clinical pediatric diseases.
本研究旨在通过前瞻性研究建立儿童血清淀粉酶和脂肪酶的年龄和性别特异性参考区间。在中国吉林省五个行政区域的社区和学校中，共招募了 6466 名健康汉族儿童，年龄为 1 个月至<18 岁。采用 VITROS 5600 集成系统测定血清淀粉酶和脂肪酶浓度。参考区间通过非参数 95%百分位区间定义。淀粉酶的参考区间分为四个年龄特异性分区。1 个月至<1 岁和 1 至<5 岁之间快速增加，5 至<12 岁之间略有下降，12 至<18 岁之间缓慢增加。1 岁以后，脂肪酶浓度存在性别差异，男性参考区间分为 2 个分区，女性分为 3 个分区。男性和女性的脂肪酶浓度均呈上升趋势，女性脂肪酶浓度高于男性。本研究建立了中国健康儿童血清淀粉酶和脂肪酶的参考区间，为临床儿科疾病的诊断和预后提供了更准确的解释。
