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致癌和抑癌 miRNA 类型在埃及子宫癌患者中的预后作用。

Prognostic Role of Oncogenic and Tumor-Suppressing miRNA Types in Egyptian Uterine Cancer Patients.

机构信息

Department of Zoology, Research Lab. for Molecular Carcinogenesis, Faculty of Science, Tanta University, Tanta 31527, Egypt.

Department of Chemistry, Biochemistry Division, Faculty of Science, Damanhour University, Damanhour 22516, Egypt.

出版信息

Asian Pac J Cancer Prev. 2022 Aug 1;23(8):2607-2615. doi: 10.31557/APJCP.2022.23.8.2607.

DOI:10.31557/APJCP.2022.23.8.2607
PMID:36037113
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9741901/
Abstract

OBJECTIVE

Uterine or endometrial cancer affects many women postmenopausal and may reach an advanced stage before signs and symptoms can be noticed. Micro RNAs (miRNAs), non-coding RNAs, play key roles in gene expression regulation and are linked to cancer. This study aimed to elucidate whether some specific types of miRNAs (miRNA133-a, miRNA-21, miRNA-205) can act as prognostic or diagnostic biomarkers for endometrial carcinoma (ER) in Egyptian patients.

METHODS

Blood samples from 36 patients suffering from endometrial carcinoma and 15 healthy volunteers were tested for expression levels of miRNA 133a-2, 21 and 205.

RESULTS

The expression levels of miRNA133a-2, miRNA-21, and miRNA-205 were significantly elevated in ER patients when compared with the control group, the highest levels were noticed in miRNA133a-2. The CA125 levels were significantly higher in all patients as compared with healthy subjects.

CONCLUSION

The findings could support the use of circulating miR133a-2, miR-21 and miR-205 as virtuous prognostic biomarkers for EC in Egyptian patients. The studied miRNA species warrant validation for prospective targeting inhibitory protocols in EC.

摘要

目的

子宫或子宫内膜癌影响许多绝经后妇女，并且在出现体征和症状之前可能已经发展到晚期。微小 RNA（miRNA）是非编码 RNA，在基因表达调控中发挥着关键作用，并与癌症有关。本研究旨在阐明某些特定类型的 miRNA（miRNA133-a、miRNA-21、miRNA-205）是否可以作为埃及患者子宫内膜癌（ER）的预后或诊断生物标志物。

方法

检测 36 名子宫内膜癌患者和 15 名健康志愿者的血液样本中 miRNA133a-2、21 和 205 的表达水平。

结果

与对照组相比，ER 患者的 miRNA133a-2、miRNA-21 和 miRNA-205 的表达水平显着升高，miRNA133a-2 的水平最高。与健康受试者相比，所有患者的 CA125 水平均显着升高。

结论

这些发现可能支持将循环 miR133a-2、miR-21 和 miR-205 用作埃及患者 EC 的良性预后生物标志物。所研究的 miRNA 种类需要在 EC 中进行前瞻性靶向抑制方案的验证。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d47c/9741901/e9b25ac9dd14/APJCP-23-2607-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d47c/9741901/b7fb2bcbe512/APJCP-23-2607-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d47c/9741901/fd1f30031290/APJCP-23-2607-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d47c/9741901/a237a3120121/APJCP-23-2607-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d47c/9741901/e9b25ac9dd14/APJCP-23-2607-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d47c/9741901/b7fb2bcbe512/APJCP-23-2607-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d47c/9741901/fd1f30031290/APJCP-23-2607-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d47c/9741901/a237a3120121/APJCP-23-2607-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d47c/9741901/e9b25ac9dd14/APJCP-23-2607-g004.jpg

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