Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.
Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China; College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.
Bioorg Chem. 2022 Nov;128:106106. doi: 10.1016/j.bioorg.2022.106106. Epub 2022 Aug 24.
Natural products with diverse structures and significant biological activities are essential sources of drug lead compounds, and play an important role in the research and development of innovative drugs. Cage-like compounds have various structures and are widely distributed in nature, especially caged xanthones isolated from Garcinia genus, paeoniflorin and its derivatives isolated from Paeonia lactiflora Pall, tetrodotoxin (TTX) and its derivatives, and so on. In recent years, the development and utilization of cage-like compounds have been a research hotspot in chemistry, biology and other fields due to their special structures and remarkable biological activities. In this review, we mainly summarized the cage-like compounds with various structures found and isolated from natural drugs since 1956, summarized its broad biological activities, and introduced the progress in the biosynthesis of some compounds, so as to provide a reference for the discovery of more novel compounds, and the development and application of innovative drugs.
具有多样结构和显著生物活性的天然产物是药物先导化合物的重要来源，在创新药物的研究和开发中发挥着重要作用。笼状化合物具有多种结构，广泛分布于自然界中，特别是从藤黄属植物中分离得到的笼状黄烷酮、从白芍中分离得到的芍药苷及其衍生物、河豚毒素（TTX）及其衍生物等。近年来，由于其特殊的结构和显著的生物活性，笼状化合物的开发和利用成为化学、生物学等领域的研究热点。本文主要综述了自 1956 年以来从天然药物中发现和分离得到的具有多种结构的笼状化合物，总结了其广泛的生物活性，并介绍了部分化合物生物合成的研究进展，以期为更多新型化合物的发现以及创新药物的开发和应用提供参考。
