Department of Medical and Surgical Sciences and Translational Medicine, PhD Course in "Translational Medicine and Oncology", Sapienza University, Rome, Italy.
Department of Medical and Surgical Sciences and Translational Medicine, PhD Course in "Translational Medicine and Oncology", Sapienza University, Rome, Italy.
Eur J Obstet Gynecol Reprod Biol. 2022 Oct;277:84-89. doi: 10.1016/j.ejogrb.2022.08.012. Epub 2022 Aug 24.
One of the most common adverse events reported by gynecological cancer survivors with spontaneous or iatrogenic menopause is vulvo-vaginal atrophy (VVA). An increasing number of women have this kind of discomfort related to the menopause induced by different cancer therapies. In this regard, fractional CO2 laser may be a valid therapeutic choice for these patients.
We performed a literature search of PubMed, EMBASE, SCOPUS and Web of Science databases with search terms of laser CO2 treatment of vulvovaginal atrophy and gynecologic cancer survivors and reviewed major US Society Guidelines to create this narrative review of this topic. Breast, ovarian endometrial and cervical cancers were included.
Nine studies were included. Fractional CO2 laser improves clinical symptoms and sexual function, in terms of VHI (vaginal health index) and FSFI (female sexual function index). Non severe adverse event occurred.
According to the best evidence available, fractional CO2 laser treatment for VVA is an effective and safe therapeutic option for gynecological cancer survivors, improving sexual life and quality of life (QoL).
自发性或医源性绝经的妇科癌症幸存者最常见的不良反应之一是阴道萎缩（VA）。越来越多的妇女因不同的癌症治疗引起的绝经而出现这种不适。在这方面，分 子 CO2 激光可能是这些患者的有效治疗选择。
我们使用激光 CO2 治疗阴道萎缩和妇科癌症幸存者的检索词，在 PubMed、EMBASE、SCOPUS 和 Web of Science 数据库中进行了文献检索，并查阅了美国主要学会指南，以对此主题进行叙述性综述。包括乳腺癌、卵巢癌、子宫内膜癌和宫颈癌。
纳入了 9 项研究。分 子 CO2 激光可改善临床症状和性功能，表现在 VHI（阴道健康指数）和 FSFI（女性性功能指数）方面。未发生严重不良事件。
根据现有最佳证据，分 子 CO2 激光治疗 VA 是妇科癌症幸存者的一种有效且安全的治疗选择，可改善性生活和生活质量（QoL）。
