Atlihan Ufuk, Ata Can, Yavuz Onur, Avsar Huseyin Aytug, Erkilinc Selcuk, Bildaci Tevfik Berk
Department of Obstetrics and Gynecology, Merkezefendi Hospital, Manisa, Türkiye.
Department of Obstetrics and Gynecology, Buca Seyfi Demirsoy Training and Research Hospital, İzmir Democracy University, İzmir, Türkiye.
Front Med (Lausanne). 2025 May 19;12:1590078. doi: 10.3389/fmed.2025.1590078. eCollection 2025.
Platelet-rich plasma (PRP) is considered safe and is a low-cost, simple, natural, and minimally invasive method for vaginal rejuvenation. We aimed to compare the effects of hormonal treatment options and PRP use for postmenopausal vulvovaginal atrophy (VVA).
From a total of 66 patients, topical estrogen treatment was administered to 36 patients, and PRP treatment was used on 30 patients who had previously received topical estrogen treatment without obtaining a response. To assess the impact of VVA and associated symptoms on the quality of life of patients, three different questionnaires, namely the Vaginal Health Index (VHI), Female Sexual Function Index (FSFI), and the Vulvovaginal Symptoms Questionnaire (VSQ), along with a Visual Analog Scale (VAS), were administered at 4-week intervals.
In the assessment at the 12th week, the FSFI and VSQ results obtained in patients treated with PRP showed a significant difference compared with those treated with topical estrogen ( = 0.004 and < 0.001, respectively).
PRP injections are a safe and effective minimally invasive monotherapy for postmenopausal VVA and, consequently, vulvovaginal rejuvenation. PRP injections are regarded as a promising method for the treatment of VVA in postmenopausal patients with contraindications to hormone therapy and improving hydration of the vaginal mucosa.
富血小板血浆（PRP）被认为是安全的，是一种用于阴道年轻化的低成本、简单、天然且微创的方法。我们旨在比较激素治疗方案和PRP用于绝经后外阴阴道萎缩（VVA）的效果。
在总共66例患者中，36例患者接受局部雌激素治疗，30例先前接受局部雌激素治疗但无反应的患者采用PRP治疗。为了评估VVA及其相关症状对患者生活质量的影响，每隔4周进行三种不同的问卷调查，即阴道健康指数（VHI）、女性性功能指数（FSFI）和外阴阴道症状问卷（VSQ），同时使用视觉模拟量表（VAS）。
在第12周的评估中，接受PRP治疗的患者获得的FSFI和VSQ结果与接受局部雌激素治疗的患者相比有显著差异（分别为=0.004和<0.001）。
PRP注射是一种安全有效的微创单一疗法，用于治疗绝经后VVA，从而实现外阴阴道年轻化。PRP注射被认为是一种有前景的方法，可用于治疗有激素治疗禁忌证的绝经后患者的VVA，并改善阴道黏膜的水合作用。
