University Institute of Diagnostic and Interventional Neuroradiology, Bern University Hospital, Inselspital, University of Bern, Bern, Switzerland.
Department of Otorhinolaryngology and Head & Neck Surgery, Inselspital, University of Bern, Bern, Switzerland.
Audiol Neurootol. 2022;27(6):449-457. doi: 10.1159/000525419. Epub 2022 Aug 29.
The aim of this study is to evaluate signal alteration in the inner ear using three-dimensional (3D)-constructive interference in steady state (CISS) sequence in patients with Ménière's disease and labyrinthitis and its correlation with clinical and audiological parameters.
The medical records of the department of otorhinolaryngology were searched for patients with Ménière's disease or labyrinthitis who underwent MRI with 3D-CISS sequence. Blinded analysis of these patients and of MRI from control subjects without middle or inner ear symptoms was performed to detect any signal asymmetry of the inner ear structures. The results were correlated with clinical symptoms and results of audiological and vestibular tests.
Fifty-eight patients with definite Ménière's disease and 5 patients with labyrinthitis as well as 41 control exams were included. A separate analysis was performed for patients with probable Ménière's disease (n = 68). A total of 172 3D-CISS sequences were analyzed by 2 blinded independent neuroradiologists. A CISS-hypointense signal of the inner ear structures was found in 3 patients with definite Ménière's disease (5.2%), in 4 patients with probable Ménière's disease (5.9%), and 2 patients with labyrinthitis (40%). No CISS hypointensity was found in the control group. Although no significant difference in symptoms or audiological test results was found between patients with and without this signal change, the side of hypointensity was frequently correlated with the symptomatic side and with hearing impairment.
DISCUSSION/CONCLUSION: CISS hypointensity of the inner ear structures was evident in patients with clinical conditions other than vestibular schwannoma - more frequently in labyrinthitis than in Ménière's disease. This signal alteration was frequently encountered on the same symptomatic side as that of the pathological audiology tests, but it is not a predictor for hearing or vestibular impairment.
本研究旨在评估三维（3D）稳态构建干扰（CISS）序列中耳内信号改变在梅尼埃病和迷路炎患者中的表现，并分析其与临床和听力学参数的相关性。
检索耳鼻喉科的病历，寻找患有梅尼埃病或迷路炎并接受 3D-CISS 序列 MRI 的患者。对这些患者和无中耳或内耳症状的 MRI 进行盲法分析，以检测内耳结构的任何信号不对称。将结果与临床症状以及听力学和前庭测试的结果相关联。
共纳入 58 例确诊梅尼埃病患者、5 例迷路炎患者和 41 例对照组患者。对疑似梅尼埃病患者（n=68）进行了单独分析。共有 2 名盲法独立神经放射科医生对 172 个 3D-CISS 序列进行了分析。3 例确诊梅尼埃病患者（5.2%）、4 例疑似梅尼埃病患者（5.9%）和 2 例迷路炎患者（40%）的内耳结构出现 CISS 信号低强度。对照组未发现 CISS 信号低强度。尽管有此信号改变的患者与无症状患者在症状或听力学测试结果方面无显著差异，但低信号侧与症状侧和听力损失相关。
讨论/结论：除前庭神经鞘瘤外，其他临床情况下也可见内耳结构的 CISS 信号低强度，在迷路炎中比在梅尼埃病中更常见。这种信号改变常发生在与病理性听力学测试相同的症状侧，但它不是听力或前庭损伤的预测因素。
