Cardoso Marlon H, Meneguetti Beatriz T, Oliveira-Júnior Nelson G, Macedo Maria L R, Franco Octávio L
S-inova Biotech, Programa de Pós-Graduação em Biotecnologia, Universidade Católica Dom Bosco, Campo Grande, MS 79117900, Brazil; Centro de Análises Proteômicas e Bioquímicas, Pós-Graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília, Brasília, DF 70790160, Brazil; Laboratório de Purificação de Proteínas e suas Funções Biológicas, Universidade Federal de Mato Grosso do Sul, Cidade Universitária, 79070900 Campo Grande, Mato Grosso do Sul, Brazil.
S-inova Biotech, Programa de Pós-Graduação em Biotecnologia, Universidade Católica Dom Bosco, Campo Grande, MS 79117900, Brazil.
Peptides. 2022 Nov;157:170865. doi: 10.1016/j.peptides.2022.170865. Epub 2022 Aug 28.
The gut microbiota presents essential functions in the immune response. The gut epithelium acts as a protective barrier and, therefore, can produce several antimicrobial peptides (AMPs) that can act against pathogenic microorganisms, including bacteria. Several factors cause a disturbance in gut microbiota, including the exacerbated and erroneous use of antibiotics. Antibiotic therapy has been closely related to bacterial resistance and is also correlated with undesired side-effects to the host, including the eradication of commensal bacteria. Consequently, this results in gut microbiota imbalance and inflammatory bowel diseases (IBD) development. In this context, AMPs in the gut epithelium play a restructuring role for gut microbiota. Some naturally occurring AMPs are selective for pathogenic bacteria, thus preserving the health microbiota. Therefore, AMPs produced by the host's epithelial cells represent effective molecules in treating gut bacterial infections. Bearing this in mind, this review focused on describing the importance of the host's AMPs in gut microbiota modulation and their role as anti-infective agents against pathogenic bacteria.
肠道微生物群在免疫反应中发挥着重要作用。肠道上皮作为一道保护屏障，因此能够产生多种抗菌肽（AMPs），这些抗菌肽可以对抗包括细菌在内的致病微生物。多种因素会导致肠道微生物群紊乱，其中包括对抗生素的过度和错误使用。抗生素治疗与细菌耐药性密切相关，并且还与对宿主的不良副作用有关，包括共生细菌的根除。因此，这会导致肠道微生物群失衡和炎症性肠病（IBD）的发展。在这种情况下，肠道上皮中的抗菌肽对肠道微生物群起着重塑作用。一些天然存在的抗菌肽对病原菌具有选择性，从而保护健康的微生物群。因此，宿主上皮细胞产生的抗菌肽是治疗肠道细菌感染的有效分子。考虑到这一点，本综述着重描述宿主抗菌肽在调节肠道微生物群中的重要性及其作为抗病原菌感染剂的作用。
