Division of Neonatology, Department of Pediatrics, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, China.
Department of Perinatology, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, China.
Pediatr Nephrol. 2023 Nov;38(11):3529-3547. doi: 10.1007/s00467-023-05931-z. Epub 2023 Mar 30.
One of the most frequent issues in newborns is acute kidney injury (AKI), which can lengthen their hospital stay or potentially raise their chance of dying. The gut-kidney axis establishes a bidirectional interplay between gut microbiota and kidney illness, particularly AKI, and demonstrates the importance of gut microbiota to host health. Since the ability to predict neonatal AKI using blood creatinine and urine output as evaluation parameters is somewhat constrained, a number of interesting biomarkers have been developed. There are few in-depth studies on the relationships between these neonatal AKI indicators and gut microbiota. In order to gain fresh insights into the gut-kidney axis of neonatal AKI, this review is based on the gut-kidney axis and describes relationships between gut microbiota and neonatal AKI biomarkers.
新生儿最常见的问题之一是急性肾损伤（AKI），这可能会延长他们的住院时间或增加其死亡风险。肠-肾轴在肠道微生物群和肾脏疾病（特别是 AKI）之间建立了双向相互作用，并表明了肠道微生物群对宿主健康的重要性。由于使用血肌酐和尿输出作为评估参数来预测新生儿 AKI 的能力有些受限，因此已经开发了许多有趣的生物标志物。这些新生儿 AKI 指标与肠道微生物群之间的关系的深入研究很少。为了更深入地了解新生儿 AKI 的肠-肾轴，本综述基于肠-肾轴，并描述了肠道微生物群与新生儿 AKI 生物标志物之间的关系。
