Jin W J, Wang Y Y, Gao S L, Niu Z L, Ning Z Q, Zhang Y, Shao J G
Department of Infection, Suzhou Ninth People's Hospital, Suzhou 215200, China.
Key Laboratory of Public Health Safety of Ministry of Education, Department of Epidemiology, School of Public Health, Fudan University, Shanghai 200032, China.
Zhonghua Gan Zang Bing Za Zhi. 2022 Jul 20;30(7):763-769. doi: 10.3760/cma.j.cn501113-20210519-00241.
To analyze the trend of liver cancer morbidity and mortality among residents with household registration in certain District, 2017 to 2019. The crude morbidity and mortality rate of males and females in the whole population were calculated by using the relevant data from the certain District Cancer Registry and Report System and the Cause of Death Surveillance System. The standardized morbidity and mortality rate were calculated according to the age structure of 2000 National Demographic Census and Segi's world population, respectively. Trend in liver cancer morbidity and mortality were evaluated using percent change (PC), annual percentage change, and case-number-weighted annual percent change. Age-specific rates were used to analyze the epidemic trend of liver cancer with age. The crude morbidity rate of liver cancer in the whole population (male and female) of the certain district from 2017 to 2019 were 18.86/100 000, 26.05/100 000 and 11.90/100 000 respectively, and the crude mortality rates were 21.20/100 000, 29.29/100 000 and 13.38/100 000 respectively. The crude morbidity and mortality rate of liver cancer among male showed a downward trend (PC=-16.77% and -20.15% respectively). The crude morbidity and mortality rate of liver cancer among female showed inconsistent changes; however, the crude morbidity rate showed a downward trend, and the crude mortality rate first increased and then decreased (PC=-19.42% and -0.30% respectively). Liver cancer morbidity and mortality rate in male after the age of 30 were increased with age. The two key points of accelerated growth were around the age of 65 and 75, and the peak of morbidity (130.78/100 000) and mortality (201.96/100 000) were after the age of 80. The morbidity and mortality rate were significantly lower in female than those of male aged 60; however, after the age of 65, the morbidity rate was increased rapidly and gradually approached as that of male. After the age of 80 (the peak morbidity and mortality were 104.40/100,000 and 132.87/100,000, respectively), male were about twice as high as those female aged between 75 and 79. Morbidity and mortality rate of liver cancer in the certain District showed an overall downward trend from 2017 to 2019, but it increased with age, and the disease burden was relatively high among the elderly population. Liver cancer mostly occurred in male, so the prevention and control of liver cancer epidemics in middle-aged and elderly should be actively monitored.
分析2017年至2019年某区户籍居民肝癌发病和死亡趋势。利用某区癌症登记报告系统和死因监测系统的相关数据，计算全人群中男性和女性的粗发病率和死亡率。分别根据2000年全国人口普查的年龄结构和Segi世界人口计算标准化发病率和死亡率。使用百分比变化（PC）、年百分比变化和病例数加权年百分比变化评估肝癌发病和死亡趋势。采用年龄别发病率分析肝癌的年龄流行趋势。2017年至2019年某区全人群（男性和女性）肝癌粗发病率分别为18.86/10万、26.05/10万和11.90/10万，粗死亡率分别为21.20/10万、29.29/10万和13.38/10万。男性肝癌粗发病率和死亡率呈下降趋势（PC分别为-16.77%和-20.15%）。女性肝癌粗发病率和死亡率变化不一致；然而，粗发病率呈下降趋势，粗死亡率先上升后下降（PC分别为-19.42%和-0.30%）。30岁以后男性肝癌发病率和死亡率随年龄增加。加速增长的两个关键点分别在65岁和75岁左右，发病率（130.78/10万）和死亡率（201.96/10万）的峰值出现在80岁以后。60岁时女性发病率和死亡率显著低于男性；然而，65岁以后，发病率迅速上升并逐渐接近男性。80岁以后（发病率和死亡率峰值分别为104.40/10万和132.87/10万），75至79岁男性发病率和死亡率约为女性的两倍。2017年至2019年某区肝癌发病率和死亡率总体呈下降趋势，但随年龄增加而上升，老年人群疾病负担相对较高。肝癌主要发生在男性，因此应积极监测中老年人群肝癌流行情况的防控。
