Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, TaiKang Center for Life and Medical Sciences, Wuhan University, Wuhan, 430072, China.
Frontier Science Center for Immunology and Metabolism, Medical Research Institute, Wuhan University, Wuhan, 430071, China.
J Hematol Oncol. 2022 Aug 29;15(1):120. doi: 10.1186/s13045-022-01340-1.
Metabolic reprogramming of cancer cells within the tumor microenvironment typically occurs in response to increased nutritional, translation and proliferative demands. Altered lipid metabolism is a marker of tumor progression that is frequently observed in aggressive tumors with poor prognosis. Underlying these abnormal metabolic behaviors are posttranslational modifications (PTMs) of lipid metabolism-related enzymes and other factors that can impact their activity and/or subcellular localization. This review focuses on the roles of these PTMs and specifically on how they permit the re-wiring of cancer lipid metabolism, particularly within the context of the tumor microenvironment.
肿瘤微环境中的癌细胞代谢重编程通常是对营养、翻译和增殖需求增加的反应。改变的脂质代谢是肿瘤进展的标志，在预后不良的侵袭性肿瘤中经常观察到。在这些异常代谢行为的背后，是脂质代谢相关酶和其他因素的翻译后修饰（PTMs），这些修饰可以影响它们的活性和/或亚细胞定位。这篇综述重点介绍了这些 PTMs 的作用，特别是它们如何允许重新连接癌症的脂质代谢，特别是在肿瘤微环境的背景下。
