Feng Tianyu, Zhang He, Zhou Yanjie, Zhu Yalan, Shi Shiya, Li Kai, Lin Ping, Chen Jie
Department of Laboratory Medicine, West China Hospital, Sichuan University, #37, Guo Xue Lane, Chengdu, Sichuan Province, 610041, China.
Sichuan Clinical Research Center for Laboratory Medicine, Chengdu, Sichuan Province, 610041, China.
Biomark Res. 2024 Nov 18;12(1):141. doi: 10.1186/s40364-024-00681-y.
Lipid metabolism reprogramming has emerged as a hallmark of malignant tumors. Lipids represent a complex group of biomolecules that not only compose the essential components of biological membranes and act as an energy source, but also function as messengers to integrate various signaling pathways. In tumor cells, de novo lipogenesis plays a crucial role in acquiring lipids to meet the demands of rapid growth. Increasing evidence has suggested that dysregulated lipid metabolism serves as a driver of cancer progression. Posttranslational modifications (PTMs), which occurs in most eukaryotic proteins throughout their lifetimes, affect the activity, abundance, function, localization, and interactions of target proteins. PTMs of crucial molecules are potential intervention sites and are emerging as promising strategies for the cancer treatment. However, there is limited information available regarding the PTMs that occur in cancer lipid metabolism and the potential treatment strategies associated with these PTMs. Herein, we summarize current knowledge of the roles and regulatory mechanisms of PTMs in lipid metabolism. Understanding the roles of PTMs in lipid metabolism in cancer could provide valuable insights into tumorigenesis and progression. Moreover, targeting PTMs in cancer lipid metabolism might represent a promising novel therapeutic strategy.
脂质代谢重编程已成为恶性肿瘤的一个标志。脂质是一类复杂的生物分子，它们不仅构成生物膜的基本成分并充当能量来源，还作为信使整合各种信号通路。在肿瘤细胞中，从头脂肪生成在获取脂质以满足快速生长需求方面起着关键作用。越来越多的证据表明，失调的脂质代谢是癌症进展的驱动因素。翻译后修饰（PTM）发生在大多数真核生物蛋白质的整个生命周期中，影响靶蛋白的活性、丰度、功能、定位和相互作用。关键分子的PTM是潜在的干预位点，并正在成为有前景的癌症治疗策略。然而，关于癌症脂质代谢中发生的PTM以及与这些PTM相关的潜在治疗策略的信息有限。在此，我们总结了目前关于PTM在脂质代谢中的作用和调控机制的知识。了解PTM在癌症脂质代谢中的作用可以为肿瘤发生和进展提供有价值的见解。此外，针对癌症脂质代谢中的PTM可能代表一种有前景的新型治疗策略。
