Department of Gastroenterology, Jiangsu University Cancer Institute, Affiliated Hospital of Jiangsu University, 438 Jiefang Road, Jingkou, Zhenjiang, Jiangsu, 212001, P. R. China.
Digestive Disease Research Institute of Jiangsu University, Zhenjiang, 212001, Jiangsu, China.
Lipids Health Dis. 2024 Feb 1;23(1):35. doi: 10.1186/s12944-024-02024-0.
Lipid metabolism in cancer cells has garnered increasing attention in recent decades. Cancer cells thrive in hypoxic conditions, nutrient deficiency, and oxidative stress and cannot be separated from alterations in lipid metabolism. Therefore, cancer cells exhibit increased lipid metabolism, lipid uptake, lipogenesis and storage to adapt to a progressively challenging environment, which contribute to their rapid growth. Lipids aid cancer cell activation. Cancer cells absorb lipids with the help of transporter and translocase proteins to obtain energy. Abnormal levels of a series of lipid synthases contribute to the over-accumulation of lipids in the tumor microenvironment (TME). Lipid reprogramming plays an essential role in the TME. Lipids are closely linked to several immune cells and their phenotypic transformation. The reprogramming of tumor lipid metabolism further promotes immunosuppression, which leads to immune escape. This event significantly affects the progression, treatment, recurrence, and metastasis of cancer. Therefore, the present review describes alterations in the lipid metabolism of immune cells in the TME and examines the connection between lipid metabolism and immunotherapy.
近年来，癌细胞中的脂质代谢受到了越来越多的关注。癌细胞在缺氧、营养缺乏和氧化应激的条件下茁壮成长，与脂质代谢的改变密不可分。因此，癌细胞表现出增强的脂质代谢、脂质摄取、脂肪生成和储存，以适应日益严峻的环境，这有助于它们的快速生长。脂质有助于癌细胞的激活。癌细胞在转运体和移位酶蛋白的帮助下吸收脂质以获取能量。一系列脂质合酶的异常水平导致肿瘤微环境（TME）中脂质的过度积累。脂质重编程在 TME 中起着至关重要的作用。脂质与几种免疫细胞及其表型转化密切相关。肿瘤脂质代谢的重编程进一步促进了免疫抑制，导致免疫逃逸。这一事件显著影响癌症的进展、治疗、复发和转移。因此，本综述描述了 TME 中免疫细胞的脂质代谢改变，并探讨了脂质代谢与免疫治疗之间的联系。
